COMPARISION OF ELECTROCARDIOGRAM CHANGES AND NA+, K+, CA2+AND MG2+ LEVELS OF SERUM AND URINE IN BOLUS INJECTION AND CONTINOUS INFUSION OF FUROSEMIDE IN DOG

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NESHAT GHARAMALEKY M.; KHAYAT NOURI M.H.; MOUSAVI GH.; KHALEJ R.; RIAZI S.F.

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Journal: JOURNAL OF VETERINARY MICROBIOLOGY Year:2010 | Volume:6 | Issue:1 (19) Page(s): 11-17

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Title

COMPARISION OF ELECTROCARDIOGRAM CHANGES AND NA+, K+, CA2+AND MG2+ LEVELS OF SERUM AND URINE IN BOLUS INJECTION AND CONTINOUS INFUSION OF FUROSEMIDE IN DOG

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Keywords

FUROSEMIDEQ3

SERUM AND URINE CATIONESQ3

ELECTROCARDIOGRAMQ3

DOGQ2

Abstract

FUROSEMIDE is a loop diuretic that with affecting on ascending part of henles tubule, increase urine volume. With attention to direct effect of FUROSEMIDE on Na+, K+, Ca2+ and Mg2+ levels and cell functions (neuron, heart, muscle), it seems that the route of administration of FUROSEMIDE, can influence the level of abovementhioned cations. When this drug can be effective that has minimum changes on electrolyte levels. In this study we compare the bolus injection versus continues infusion of FUROSEMIDE on ELECTROCARDIOGRAM changes and Na+, K+, Ca2+ and Mg2+ levels of serum and urine. In this study, sixtheen domestic male DOGs were selected randomally and divided to two groups. In group 1, bolus injection of FUROSEMIDE (6mg/kg) and in group 2, continous infusion of FUROSEMIDE with same dose were administrated. Then in both group before (time 0) and 30 minute, one, two, four and eight hour after injection, ELECTROCARDIOGRAM were recorded and urine and serum electrolyte levels were collected. In ELECTROCARDIOGRAM heart rate (HR), P wave duration (PD), P wave amplitude (PA), PR interval (PR int), QRS duration (QRS D), R amplitude (RA), ST segment (ST seg) and QT interval (QT int) were evaluated. Result showed that the urine level of sodium in bolus injection of FUROSEMIDE significantly increased (p<0.05) compared with continuous infusion. Also we did not found any significant change in ELECTROCARDIOGRAM. However study of cardiac function and electrolyte disturbance needs to more investigation.

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APA: Copy

NESHAT GHARAMALEKY, M., KHAYAT NOURI, M.H., MOUSAVI, GH., KHALEJ, R., & RIAZI, S.F.. (2010). COMPARISION OF ELECTROCARDIOGRAM CHANGES AND NA+, K+, CA2+AND MG2+ LEVELS OF SERUM AND URINE IN BOLUS INJECTION AND CONTINOUS INFUSION OF FUROSEMIDE IN DOG. JOURNAL OF VETERINARY MICROBIOLOGY, 6(1 (19)), 11-17. SID. https://sid.ir/paper/152023/en

Vancouver: Copy

NESHAT GHARAMALEKY M., KHAYAT NOURI M.H., MOUSAVI GH., KHALEJ R., RIAZI S.F.. COMPARISION OF ELECTROCARDIOGRAM CHANGES AND NA+, K+, CA2+AND MG2+ LEVELS OF SERUM AND URINE IN BOLUS INJECTION AND CONTINOUS INFUSION OF FUROSEMIDE IN DOG. JOURNAL OF VETERINARY MICROBIOLOGY[Internet]. 2010;6(1 (19)):11-17. Available from: https://sid.ir/paper/152023/en

IEEE: Copy

M. NESHAT GHARAMALEKY, M.H. KHAYAT NOURI, GH. MOUSAVI, R. KHALEJ, and S.F. RIAZI, “COMPARISION OF ELECTROCARDIOGRAM CHANGES AND NA+, K+, CA2+AND MG2+ LEVELS OF SERUM AND URINE IN BOLUS INJECTION AND CONTINOUS INFUSION OF FUROSEMIDE IN DOG,” JOURNAL OF VETERINARY MICROBIOLOGY, vol. 6, no. 1 (19), pp. 11–17, 2010, [Online]. Available: https://sid.ir/paper/152023/en

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