Evaluation of Betaine Neuroprotective Effects on 6-Hydroxy Dopamine Induced Hemi Parkinsonism in Male Wistar Rats

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RAHMANI BEHROUZ; ZENDEHDEL MORTEZA; BABAPOUR VAHAB; SADEGHINEZHAD JAVAD; ALIREZAEI MASOUD

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Journal: Iranian Journal of Veterinary Medicine Year:2019 | Volume:13 | Issue:3 Page(s): 290-302

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Title

Evaluation of Betaine Neuroprotective Effects on 6-Hydroxy Dopamine Induced Hemi Parkinsonism in Male Wistar Rats

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Keywords

betaineQ1

homocysteine (Hcy)Q2

6-Hydroxydopamine (6-OHDA)Q1

malondyaldehyde (MDA)Q2

Parkinson's disease (PD)Q1

Abstract

BACKGROUND: Parkinson's disease (PD) is one of the prevalent debilitating neurodegenerative disorders. Accordingly, researchers are working on methods to modify PD progression. Previously, the neuroprotective effects of betaine, as a methyl donor agent in homocysteine metabolism, have been demonstrated in animal models of chronic cerebral hypoperfusion and memory deficits. OBJECTIVES: It was aimed to investigate the neuroprotective effects of betaine in an animal model of PD. METHODS: In male Wistar rats under two-week course of oral betaine administration (50, 100, and 200 mg/kg per day), the behavioral, biochemical, and histological evaluations were conducted one week following unilateral nigral 6-OHDA injection. RESUTLS: betaine administration with dose of 200 mg/kg, one week before and after 6-OHDA lesioning, was associated with a meaningful reduction in the plasma levels of homocysteine (Hcy) in comparison with the control and sham groups (P < 0. 05). Our evaluations revealed a remarkable improvement in motor asymmetry induced by apomorphine in the rats under treatment of betaine 200 mg/kg. Moreover, in this group, a significant decrease of malondyaldehyde (MDA) concentrations was detected in the brain tissues, as well as a significantly diminished neuronal cell loss (percent) in substantia nigra pars compacta (P < 0. 05). The results of 50 and 100 mg/kg betaine groups were not significant. CONCLUSIONS: Altogether, our findings indicate the antioxidant neuroprotective effects of betaine in this animal model of PD and it is in concordance with betaine properties in decreasing the plasma levels and possible neurotoxic effects of Hcy.

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APA: Copy

RAHMANI, BEHROUZ, ZENDEHDEL, MORTEZA, BABAPOUR, VAHAB, SADEGHINEZHAD, JAVAD, & ALIREZAEI, MASOUD. (2019). Evaluation of Betaine Neuroprotective Effects on 6-Hydroxy Dopamine Induced Hemi Parkinsonism in Male Wistar Rats. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 13(3 ), 290-302. SID. https://sid.ir/paper/158002/en

Vancouver: Copy

RAHMANI BEHROUZ, ZENDEHDEL MORTEZA, BABAPOUR VAHAB, SADEGHINEZHAD JAVAD, ALIREZAEI MASOUD. Evaluation of Betaine Neuroprotective Effects on 6-Hydroxy Dopamine Induced Hemi Parkinsonism in Male Wistar Rats. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2019;13(3 ):290-302. Available from: https://sid.ir/paper/158002/en

IEEE: Copy

BEHROUZ RAHMANI, MORTEZA ZENDEHDEL, VAHAB BABAPOUR, JAVAD SADEGHINEZHAD, and MASOUD ALIREZAEI, “Evaluation of Betaine Neuroprotective Effects on 6-Hydroxy Dopamine Induced Hemi Parkinsonism in Male Wistar Rats,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 13, no. 3 , pp. 290–302, 2019, [Online]. Available: https://sid.ir/paper/158002/en

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