COMPARISON OF THE FORMALIN-INDUCED PAIN RESPONSE IN NORMAL AND CHOLESTATIC MALE MICE

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KHAYAT NOURI M.H.; NASIRZADEH M.R.; TABATABAEI S.H.

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Journal: JOURNAL OF LARGE ANIMAL CLINICAL SCIENCE RESEARCH (JOURNAL OF VETERINARY MEDICINE) Year:2010 | Volume:4 | Issue:11 Page(s): 71-79

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Title

COMPARISON OF THE FORMALIN-INDUCED PAIN RESPONSE IN NORMAL AND CHOLESTATIC MALE MICE

Author(s)

KHAYAT NOURI M.H. | NASIRZADEH M.R. | TABATABAEI S.H. | Issue Writer Certificate

Keywords

CHOLESTASISQ2

ENDOGENOUS OPIOIDSQ3

PAINQ2

FORMALINQ3

MICEQ2

Abstract

Pain is one of the most important clinical signs of diseases. Considering of the most advances, PAIN treatment and other effects of PAIN, is a major challenge for medicine and researchers. A number of studies have shown that CHOLESTASIS has changed the effect of drugs on receptors and tissuses, because CHOLESTASIS induced severe pathophysiological changes on tissues and receptor number. Also increase of endogenous opioid levels has reported in some of pathologic forms such as CHOLESTASIS. So, it is important to know if these (pain and CHOLESTASIS) can have contradictive effects in one patient or not. The aim of this study was comparison of FORMALIN-induced PAIN response in normal and CHOLESTASIS MICE. In this experimental study, 30 NMRI male MICE were used and randomly divided into 3 groups, include normal, sham (surgery without bile duct ligated) and CHOLESTASIS (surgery with bile duct ligated). PAIN response evaluated in normal and seven days after operation in sham and cholestatic animals. For induced PAIN response, FORMALIN (20ml, 5%) injected intrapawley. The time of licking and biting of injected paw was measured as PAIN response at 5 minutes intervals for 1 hour. The results showed that FORMALINinduced a biphasic PAIN response. CHOLESTASIS significantly decreased (p<0.05) the first (neurogenic PAIN) and no significantly decreased (p>0.05) second phase (inflammatory PAIN) of PAIN response. Our results suggested that the CHOLESTASIS reduce nociceptive and inflammatory effect probably via an increase on the ENDOGENOUS OPIOIDS.

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References

THE EFFECT OF INTRAPERITONEAL INJECTION OF CIMETIDINE ON PAIN RESPONSE INDUCED BY FORMALIN IN MICE

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APA: Copy

KHAYAT NOURI, M.H., NASIRZADEH, M.R., & TABATABAEI, S.H.. (2010). COMPARISON OF THE FORMALIN-INDUCED PAIN RESPONSE IN NORMAL AND CHOLESTATIC MALE MICE. JOURNAL OF LARGE ANIMAL CLINICAL SCIENCE RESEARCH (JOURNAL OF VETERINARY MEDICINE), 4(11), 71-79. SID. https://sid.ir/paper/175633/en

Vancouver: Copy

KHAYAT NOURI M.H., NASIRZADEH M.R., TABATABAEI S.H.. COMPARISON OF THE FORMALIN-INDUCED PAIN RESPONSE IN NORMAL AND CHOLESTATIC MALE MICE. JOURNAL OF LARGE ANIMAL CLINICAL SCIENCE RESEARCH (JOURNAL OF VETERINARY MEDICINE)[Internet]. 2010;4(11):71-79. Available from: https://sid.ir/paper/175633/en

IEEE: Copy

M.H. KHAYAT NOURI, M.R. NASIRZADEH, and S.H. TABATABAEI, “COMPARISON OF THE FORMALIN-INDUCED PAIN RESPONSE IN NORMAL AND CHOLESTATIC MALE MICE,” JOURNAL OF LARGE ANIMAL CLINICAL SCIENCE RESEARCH (JOURNAL OF VETERINARY MEDICINE), vol. 4, no. 11, pp. 71–79, 2010, [Online]. Available: https://sid.ir/paper/175633/en

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