THE EFFECT OF INTRAPERITONEAL INJECTION OF CIMETIDINE ON PAIN RESPONSE INDUCED BY FORMALIN IN MICE

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TAMADONFARD E.; MOJTEHEDAIN A.

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Journal: Journal of Veterinary Research Year:2004 | Volume:59 | Issue:4 Page(s): 373-378

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Title

THE EFFECT OF INTRAPERITONEAL INJECTION OF CIMETIDINE ON PAIN RESPONSE INDUCED BY FORMALIN IN MICE

Author(s)

TAMADONFARD E. | MOJTEHEDAIN A. | Issue Writer Certificate

Keywords

CIMETIDINEQ4

FORMALIN-INDUCED PAINQ3

MORPHINEQ3

NALOXONQ3

MICEQ4

Abstract

Objective: To investigate the peripheral effect of CIMETIDINE on formalin induced pain and MORPHINE analgesia.Design: Experimental study.Animals: A total of 72 male MICE weighing between 23-26 gr.Procedure: The animals placed in the formalin test chambers.Intraperitoneal (IP). injections of CIMETIDINE at dose rates of 5,10 and 20 mg/Kg, MORPHINE (5 mg/Kg) and CIMETIDINE (20 mg/Kg) before MORPHINE (5 mg/Kg), Subcutaneous (SC).injection of NALOXONe (5 mg/Kg) alone or before (IP). Injection of CIMETIDINE (20 mg/Kg) were performed. Following intraplantar injection of formalin (20µ1, 5%) with a 28-guage syringe, the paw licking and biting durations as pain response were measured at five minutes intervals for total 1 hour.Statistical analysis: Paired t-test, one way and repeated measures ANOVA and duncan test.Results: Intrapaw injection of normal saline induced pain at 0-5 minutes after injection. Formalin injection by the same route produced biphasic pain response (first phase: 0-5 and second phase: 20-40 min after injection) (IP). Injection of CIMETIDINE at dose rates of 5 and 10 mg/Kg had no effect, and CIMETIDINE (20 mg/Kg) without any effect on first phase, reduced the second phase of pain (IP). injection of MORPHINE produced analgesia by reducing the first and second phases and total 1h of pain response. CIMETIDINE (20 mg/Kg) injection before MORPHINE (5 mg/Kg) had no effect on MORPHINE analgesia injection (SC) of NALOXONe (5 mg/Kg) didn't changed the formalin induced pain phases. CIMETIDINE injection after NALOXONe without any effect on first phase, reduced the second phase of noloxane hyperalgesia.Clinical implication: By the present study it is concluded that CIMETIDINE (histamine H2 antagonist) produced an analgesic effect on inflammatory but not on neurogenic phase of FORMALIN-INDUCED PAIN. Then, histamine H2 receptor may be involved in flammatory pain. It seems that in pain mechanisms, there may be not a relationship between H2 receptor and opiate system.

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APA: Copy

TAMADONFARD, E., & MOJTEHEDAIN, A.. (2004). THE EFFECT OF INTRAPERITONEAL INJECTION OF CIMETIDINE ON PAIN RESPONSE INDUCED BY FORMALIN IN MICE. JOURNAL OF VETERINARY RESEARCH, 59(4), 373-378. SID. https://sid.ir/paper/34903/en

Vancouver: Copy

TAMADONFARD E., MOJTEHEDAIN A.. THE EFFECT OF INTRAPERITONEAL INJECTION OF CIMETIDINE ON PAIN RESPONSE INDUCED BY FORMALIN IN MICE. JOURNAL OF VETERINARY RESEARCH[Internet]. 2004;59(4):373-378. Available from: https://sid.ir/paper/34903/en

IEEE: Copy

E. TAMADONFARD, and A. MOJTEHEDAIN, “THE EFFECT OF INTRAPERITONEAL INJECTION OF CIMETIDINE ON PAIN RESPONSE INDUCED BY FORMALIN IN MICE,” JOURNAL OF VETERINARY RESEARCH, vol. 59, no. 4, pp. 373–378, 2004, [Online]. Available: https://sid.ir/paper/34903/en

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