STUDY ON THE EFFECTS OF ETHANOLIC EXTRACT OF BROCCOLI ON OXIDATIVE STRESS INDUCED BY ACETAMINOPHEN IN RAT KIDNEY

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Jeddi H.; MOHAJERI D.

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Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2017 | Volume:11 | Issue:2 (42) Page(s): 145-157

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Title

STUDY ON THE EFFECTS OF ETHANOLIC EXTRACT OF BROCCOLI ON OXIDATIVE STRESS INDUCED BY ACETAMINOPHEN IN RAT KIDNEY

Author(s)

Jeddi H. | MOHAJERI D. | Issue Writer Certificate

Keywords

BRASSICA OLERACEA L. VAR. ITALICAQ1

OXIDATIVE STRESSQ2

ACETAMINOPHENQ2

KIDNEYQ2

RATQ2

Abstract

Acetaminophen overdose causes KIDNEY injury. The aim of the present study was to evaluate the protective effect of ethanolic extract of BRASSICA OLERACEA L. VAR. ITALICA against ACETAMINOPHEN -induced damage in RAT KIDNEY. Male Wistar RATs were randomly assigned into 4 groups of 8 animals each. Groups I (control) and II received intraperitoneal injections of normal saline (10 ml/kg) and ethanolic extract of broccoli (200 mg/kg) every other day for 14 days. Group III received a single intraperitoneal injection of ACETAMINOPHEN (750 mg/kg). Group IV received ethanolic extract of broccoli similar to group III after administration of a single intraperitoneal injection of ACETAMINOPHEN (750 mg/kg). At the end of experiment, serum levels of urea, uric acid and creatinine were assessed. Moreover, histopathological observations were also conducted to assess the degree of renal tissue injury. Product of lipid peroxidation (malondialdehyde) and activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase were assayed in KIDNEY homogenates. In ACETAMINOPHEN-treated RATs, ethanolic extract of broccoli significantly decreased serum urea, uric acid and creatinine and renal tissue peroxidation levels and elevated the values of anti-oxidants. Histopathologically, ethanolic extract of broccoli ameliorated ACETAMINOPHEN-induced KIDNEY injury. The results of this study indicated that ethanolic extract of broccoli exerts a protective effect against ACETAMINOPHEN induced renotoxicity in RATs which might be related to its anti-oxidant potential.

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APA: Copy

Jeddi, H., & MOHAJERI, D.. (2017). STUDY ON THE EFFECTS OF ETHANOLIC EXTRACT OF BROCCOLI ON OXIDATIVE STRESS INDUCED BY ACETAMINOPHEN IN RAT KIDNEY. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 11(2 (42) ), 145-157. SID. https://sid.ir/paper/183067/en

Vancouver: Copy

Jeddi H., MOHAJERI D.. STUDY ON THE EFFECTS OF ETHANOLIC EXTRACT OF BROCCOLI ON OXIDATIVE STRESS INDUCED BY ACETAMINOPHEN IN RAT KIDNEY. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2017;11(2 (42) ):145-157. Available from: https://sid.ir/paper/183067/en

IEEE: Copy

H. Jeddi, and D. MOHAJERI, “STUDY ON THE EFFECTS OF ETHANOLIC EXTRACT OF BROCCOLI ON OXIDATIVE STRESS INDUCED BY ACETAMINOPHEN IN RAT KIDNEY,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 11, no. 2 (42) , pp. 145–157, 2017, [Online]. Available: https://sid.ir/paper/183067/en

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