EVALUATION OF CARDIAC INJURY BIOMARKERS OF SERUM IN ALLOXAN INDUCED DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAJI SADEGHI Y.; FARTASHVAND M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2017 | Volume:11 | Issue:3 (43) Page(s): 243-249

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,013

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF CARDIAC INJURY BIOMARKERS OF SERUM IN ALLOXAN INDUCED DIABETIC RATS

Author(s)

HAJI SADEGHI Y. | FARTASHVAND M. | Issue Writer Certificate

Keywords

CARDIAC TROPONINQ2

DIABETESQ2

ALLOXANQ2

RATQ2

Abstract

Diabetes mellitus is a metabolic disorder and its incidence is considered to be high all over the world. It causes increase in blood glucose levels and subsequent damage to various tissues and blood vessels. The aim of the present study was to evaluate cardiac injury biomarkers of serum in RATs with experimental DIABETES. Thirty male Wistar RATs were randomly assigned into 2 groups including healthy control and diabetic RATs. DIABETES was induced with a single injection of ALLOXAN (120 mg/kg IP). Four weeks after induction of DIABETES, levels of cTnI (CARDIAC TROPONIN I), AST (Aspartate aminotransferase), LDH (lactate dehydrogenase) and CK-MB (keratin kinase) were measured in serum. At the end of the experiment, mean blood sugar levels were 263.1±36 and 96.7±12 mg/dl in diabetic and control groups respectively that reveals a statistically significant difference between the two groups (p=0.000). Serum cTnI level in diabetic RATs was significantly higher than healthy control group (p=0.002). Other cardiac biomarkers of serum in experimentally induced diabetic RATs were significantly higher than control group. There were significant correlation between blood glucose levels and serum cTnI (r=0.685; p=0.010), and with serum activities of enzymes, including AST (r=0.862; p=0.000), LDH (r=0.760; p=0.008) and CK-MB (r=0.590; p=0.014). In conclusion, elevated level of serum cTnI and enzyme activities in diabetic RATs in comparison to the control group suggests some degree of cardiac muscle damages.

Cites

No record.

References

No record.

Cite

APA: Copy

HAJI SADEGHI, Y., & FARTASHVAND, M.. (2017). EVALUATION OF CARDIAC INJURY BIOMARKERS OF SERUM IN ALLOXAN INDUCED DIABETIC RATS. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 11(3 (43) ), 243-249. SID. https://sid.ir/paper/183069/en

Vancouver: Copy

HAJI SADEGHI Y., FARTASHVAND M.. EVALUATION OF CARDIAC INJURY BIOMARKERS OF SERUM IN ALLOXAN INDUCED DIABETIC RATS. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2017;11(3 (43) ):243-249. Available from: https://sid.ir/paper/183069/en

IEEE: Copy

Y. HAJI SADEGHI, and M. FARTASHVAND, “EVALUATION OF CARDIAC INJURY BIOMARKERS OF SERUM IN ALLOXAN INDUCED DIABETIC RATS,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 11, no. 3 (43) , pp. 243–249, 2017, [Online]. Available: https://sid.ir/paper/183069/en

Related Journal Papers