STUDYING PREVENTIVE EFFECTS OF BERBERIS INTEGERRIMAON ROOT ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN BROILERS

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MOHAMMADI MALAYERI M.R.; DADKHAH TEHRANI A.; ORAGHI ARDEBILI Z.; NAZERI H.

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Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2013 | Volume:7 | Issue:3 (27) Page(s): 207-219

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Title

STUDYING PREVENTIVE EFFECTS OF BERBERIS INTEGERRIMAON ROOT ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN BROILERS

Author(s)

MOHAMMADI MALAYERI M.R. | DADKHAH TEHRANI A. | ORAGHI ARDEBILI Z. | NAZERI H. | Issue Writer Certificate

Keywords

BERBERIS INTEGERRIMAQ2

BROILERSQ2

HEPATOTOXICITYQ2

CARBON TETRACHLORIDEQ1

Abstract

Liver diseases and their economic losses have gained more importance alongside the development of integrated poultry industry. Studies have proved HEPATOTOXICITY induced by CARBON TETRACHLORIDE as one of the best experimental models of hepatotocicity. Barberries have been used widely in traditional medicine. The purpose of the present study was to evaluater the preventive effects of BERBERIS INTEGERRIMA root on CARBON TETRACHLORIDE induced liver lesions in BROILERS. For this purpose, 80 day old Ross strain BROILERS were divided randomly to 8 study groups consisting of negative control, positive control which received IP 4ml/kg b.w. CARBON TETRACHLORIDE twice in 25th and 28th days, treatment controls consisting of 10, 20 and 30 grams of BERBERIS INTEGERRIMA root per kilogram of diet and treatment groups consisting of 10, 20 and 30 gr. Of Berberis root / Kg diet + IP CARBON TETRACHLORIDE 4ml/Kg b.w. twice in 25th and 28th days. At 29th day, blood samples were collected from animals, then they were sacrificed and their liver samples were fixed in 10% formalin solution. The blood samples were sent to laboratory to measure ALT, AST and ALP activities. Biochemical results didn't show any significant changes of ALT, AST and ALP activities between all study groups (P>0.05). Microscopic results showed significant decrease in pathologic lesions of 20 gr Berberis root /Kg diet treatment group in comparison with the positive control group (P<0.05). The results of this study indicated that to induce more severe hepatocellular lesions in BROILERS by CARBON TETRACHLORIDE doses more than 4ml/Kg b.w are needed. Adding 20 gr BERBERIS INTEGERRIMA root /Kg diet could have preventive effects against acute hapatotoxicity induced by CARBON TETRACHLORIDE.

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APA: Copy

MOHAMMADI MALAYERI, M.R., DADKHAH TEHRANI, A., ORAGHI ARDEBILI, Z., & NAZERI, H.. (2013). STUDYING PREVENTIVE EFFECTS OF BERBERIS INTEGERRIMAON ROOT ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN BROILERS. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 7(3 (27)), 207-219. SID. https://sid.ir/paper/183097/en

Vancouver: Copy

MOHAMMADI MALAYERI M.R., DADKHAH TEHRANI A., ORAGHI ARDEBILI Z., NAZERI H.. STUDYING PREVENTIVE EFFECTS OF BERBERIS INTEGERRIMAON ROOT ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN BROILERS. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2013;7(3 (27)):207-219. Available from: https://sid.ir/paper/183097/en

IEEE: Copy

M.R. MOHAMMADI MALAYERI, A. DADKHAH TEHRANI, Z. ORAGHI ARDEBILI, and H. NAZERI, “STUDYING PREVENTIVE EFFECTS OF BERBERIS INTEGERRIMAON ROOT ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN BROILERS,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 7, no. 3 (27), pp. 207–219, 2013, [Online]. Available: https://sid.ir/paper/183097/en

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