IMMUNOHISTOCHEMICAL STUDY OF β--CATENIN IN EXPERIMENTAL COLON CARCINOMA OF RAT

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DOUSTAR Y.; MOHAJERI D.; FATHI AZAR F.; NAMVARAN A.

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Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2009 | Volume:3 | Issue:2 (10) Page(s): 451-457

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Title

IMMUNOHISTOCHEMICAL STUDY OF β--CATENIN IN EXPERIMENTAL COLON CARCINOMA OF RAT

Author(s)

DOUSTAR Y. | MOHAJERI D. | FATHI AZAR F. | NAMVARAN A. | Issue Writer Certificate

Keywords

COLONQ2

CARCINOMAQ3

β-CATENINQ3

IMMUNOHISTOCHEMISTRYQ2

Abstract

Colorectal adenocarcinoma is one of the most prevalent and treatable malignancies of the gastrointestinal tract. Recent studies on colorectal neoplasia indicate b-catenin gene mutation and its intranuclear accumulation inside hyperplastic cells. Therefore, b-catenin may be an important prognosis and diagnostic index of this disease. The aim of this study is to evaluate the nuclear beta-catenin expression in hyperplastic cells of COLON following treatment with 1,2-dimethylhydrazine. In this study, 56 wistar male rats with the age of 12 weeks and body weight of 200-300g were selected and randomly allocated into two equal treatment and control groups. In the treatment group, two subcutaneous injections of 1,2-dimethylhydrazine every week at a dose rate of 40 mg/kg were used for 4 weeks to induce COLON CARCINOMA. The control group was given normal saline solution similarly. After 8 weeks, tissues samples of distal COLON were collected from both groups for preparation of tissue sections and IMMUNOHISTOCHEMISTRY. Immunohistopathological study of samples revealed that nuclear b-catenin expression in the treatment group was significantly higher than the control group (p<0.01). The study indicates that the expression of nuclear beta-catenin can increase in hyperplasia and neoplasia of COLON.

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APA: Copy

DOUSTAR, Y., MOHAJERI, D., FATHI AZAR, F., & NAMVARAN, A.. (2009). IMMUNOHISTOCHEMICAL STUDY OF β--CATENIN IN EXPERIMENTAL COLON CARCINOMA OF RAT. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 3(2 (10)), 451-457. SID. https://sid.ir/paper/183153/en

Vancouver: Copy

DOUSTAR Y., MOHAJERI D., FATHI AZAR F., NAMVARAN A.. IMMUNOHISTOCHEMICAL STUDY OF β--CATENIN IN EXPERIMENTAL COLON CARCINOMA OF RAT. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2009;3(2 (10)):451-457. Available from: https://sid.ir/paper/183153/en

IEEE: Copy

Y. DOUSTAR, D. MOHAJERI, F. FATHI AZAR, and A. NAMVARAN, “IMMUNOHISTOCHEMICAL STUDY OF β--CATENIN IN EXPERIMENTAL COLON CARCINOMA OF RAT,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 3, no. 2 (10), pp. 451–457, 2009, [Online]. Available: https://sid.ir/paper/183153/en

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