EFFECT OF NIMODIPINE ON LINDANE-INDUCED SEIZURES IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAYAT NOURI H.; NASIRZADEH M.R.; SHEIBANI R.; MANAF HOSSEYNI A.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2011 | Volume:4 | Issue:4 (16) Page(s): 951-959

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,204

Download:

Cites:

Information Journal Paper

Title

EFFECT OF NIMODIPINE ON LINDANE-INDUCED SEIZURES IN MICE

Author(s)

KHAYAT NOURI H. | NASIRZADEH M.R. | SHEIBANI R. | MANAF HOSSEYNI A. | Issue Writer Certificate

Keywords

NIMODIPINEQ3

LINDANEQ3

SEIZUREQ2

MICEQ2

Abstract

NIMODIPINE is dihydropyridine calcium channel blocker which is widely used in a variety of cardiovascular ailments. A number of studies have shown that calcium channel blockers have anticonvulsant effect in a range of animal SEIZURE models (but not in all animals). LINDANE, an organochlorine insecticide, is widely used as a pesticide in agriculture and antiectoparasites in human and veterinary medicine. It has been shown that LINDANE is a SEIZURE-inducing agent. The aim of this study was to investigate the effect of NIMODIPINE on LINDANE-induced SEIZUREs in MICE. In this experimental study, animals were pretreated with different doses of NIMODIPINE (2.5, 5, 10, 20 and 40 mg/kg) intraperitonealy, 30 min before intraperitoneal injection of LINDANE (50 mg/kg). After injection of LINDANE, clonic and tonic SEIZUREs were investigated. Our results showed that NIMODIPINE dose dependently decreases LINDANE-induced SEIZUREs. NIMODIPINE 5 mg/kg and 40 mg/kg had the least (p<0.05) and greatest (p<0.001) anticonvulsant effects, respectively. Our results suggested that NIMODIPINE possessed anticonvulsant activity probably through its antagonistic effect on voltage-gated calcium channels.

Cites

No record.

References

No record.

Cite

APA: Copy

KHAYAT NOURI, H., NASIRZADEH, M.R., SHEIBANI, R., & MANAF HOSSEYNI, A.. (2011). EFFECT OF NIMODIPINE ON LINDANE-INDUCED SEIZURES IN MICE. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 4(4 (16)), 951-959. SID. https://sid.ir/paper/183186/en

Vancouver: Copy

KHAYAT NOURI H., NASIRZADEH M.R., SHEIBANI R., MANAF HOSSEYNI A.. EFFECT OF NIMODIPINE ON LINDANE-INDUCED SEIZURES IN MICE. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2011;4(4 (16)):951-959. Available from: https://sid.ir/paper/183186/en

IEEE: Copy

H. KHAYAT NOURI, M.R. NASIRZADEH, R. SHEIBANI, and A. MANAF HOSSEYNI, “EFFECT OF NIMODIPINE ON LINDANE-INDUCED SEIZURES IN MICE,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 4, no. 4 (16), pp. 951–959, 2011, [Online]. Available: https://sid.ir/paper/183186/en

Related Journal Papers