مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

1,218
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

3

Information Journal Paper

Title

THE STUDY OF LINDANE EFFECT ON PENTYLENETERTRAZOLE INDUCED CLONIZURE THRESHOLD IN MICE

Pages

  529-536

Abstract

 Background: The organochlorine insecticide LINDANE, is widely used as a pesticide in agriculture and against ectoparasites in human and veterinary medicine.This drug has been shown to be a seizure- inducing agent in mammals at acute and chronic dosages. The aim of this study was to evaluate the effect of LINDANE on PENTYLENETETRAZOLE- induced seizure threshold and investigate the underlying mechanism(s) responsible of this effect. Materials and Methods: In control group the seizure threshold with PENTYLENETETRAZOLE (PTZ) was 35.29±0.56 mg/kg. Mice were pretreated intraperitoneally with vehicle or LINDANE (5, 10 and 15 mg/kg) before the determination of the PTZ-induced seizure threshold. In another experiment,ivermectin (20, 40 and 60 mg/.kg), c10nazepam (0.1, 0.25 and 0.5 mg/kg) or CARBAMAZEPINE (10, 20 and 40 mg/kg) were injected intraperitoneally in mice alone or in combination with LINDANE (15 mg/kg) before PTZ administration. Results: Results showed that LINDANE significantly decreased seizure threshold. IVERMECTIN, CLONAZEPAM and CARBAMAZEPINE exhibited a dose- dependent increase in the amount of PTZ that was needed to induce a seizure. Pretreatment with IVERMECTIN, c10nazepamor CARBAMAZEPINE on the convulsant property of LINDANE on PTZ- induced seizure threshold showed that all of them significantly reversed the convulsant effect of LINDANE. However, the effects of CLONAZEPAM on PTZ convulsive threshold were more protound. Conclusions: These findings support this hypothesis that an interaction of LINDANE with the GABAA receptor/ er channel is an important mechanism underlying its neurotoxicity and the role of sodium channels in convulsant effect of LINDANE needs more investigation.  

Cites

References

  • No record.

    • Cite

    APA: Copy

    SAMINI, M., SHAFAROUDI, H., & ALLAHDINI, S.. (2005). THE STUDY OF LINDANE EFFECT ON PENTYLENETERTRAZOLE INDUCED CLONIZURE THRESHOLD IN MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 63(7), 529-536. SID. https://sid.ir/paper/39213/en

    Vancouver: Copy

    SAMINI M., SHAFAROUDI H., ALLAHDINI S.. THE STUDY OF LINDANE EFFECT ON PENTYLENETERTRAZOLE INDUCED CLONIZURE THRESHOLD IN MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;63(7):529-536. Available from: https://sid.ir/paper/39213/en

    IEEE: Copy

    M. SAMINI, H. SHAFAROUDI, and S. ALLAHDINI, “THE STUDY OF LINDANE EFFECT ON PENTYLENETERTRAZOLE INDUCED CLONIZURE THRESHOLD IN MICE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 63, no. 7, pp. 529–536, 2005, [Online]. Available: https://sid.ir/paper/39213/en

    Related Journal Papers

    Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top