A TRANSMITION ELECTRON MICROSCOPIC STUDY OF THE EFFECTS OF BAX PROTEIN ON HEPATIC LYSOSOME AND ITS ROLE IN APOPTOSIS

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RAJI A.R; YAMACHITA K.

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Journal: Year:2004 | Volume:17 | Issue:1 (62 IN ANIMAL AND FISHERIES SCIENCES) Page(s): 10-13

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Title

A TRANSMITION ELECTRON MICROSCOPIC STUDY OF THE EFFECTS OF BAX PROTEIN ON HEPATIC LYSOSOME AND ITS ROLE IN APOPTOSIS

Author(s)

RAJI A.R | YAMACHITA K. | Issue Writer Certificate

Keywords

BAX PROTEINQ4

LYSOSOMEQ4

HEPATIC CELLQ4

APOPTOSISQ2

TEMQ4

Abstract

Living cell die in two ways: Necrosis and programmed cell death (apoptosis). Necrosis is considered as an accidental death of a group of cells in a tissue. However, APOPTOSIS is induced by a variety of stimulating agents (viruses, chimicals, etc.) or is programmed in old or embryonic cells. APOPTOSIS develops as the result of two intracellular pathways: Mitochondria and death receptors. In both pathways a group of protein compounds BAX PROTEINs affect mitochondria, LYSOSOME, endoplasmic reticulum and Golgi apparatus to induce the release of caspases which in their active form induce APOPTOSIS. This study was performed to examine the ultrastractural changes of LYSOSOMEs invitro at the time of APOPTOSIS. At first LYSOSOMEs were isolated from liver using ultracentrifugation, then these agent were exposed to BAX PROTEINs at different time points. After fixation, processing, bloking and ultrathin section, the samples were imaged by a h-800 Olympus transmition electron microscope. The ultrastructural changes in LYSOSOME, induced by BAX PROTEINs were membrane shrinkage, granulation of the matrix and the rupture of membrane. This study defines the morphological feature of the changes in the ultra structure oflysosome during APOPTOSIS.

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APA: Copy

RAJI, A.R, & YAMACHITA, K.. (2004). A TRANSMITION ELECTRON MICROSCOPIC STUDY OF THE EFFECTS OF BAX PROTEIN ON HEPATIC LYSOSOME AND ITS ROLE IN APOPTOSIS. PAJOUHESH-VA-SAZANDEGI, 17(1 (62 IN ANIMAL AND FISHERIES SCIENCES)), 10-13. SID. https://sid.ir/paper/19275/en

Vancouver: Copy

RAJI A.R, YAMACHITA K.. A TRANSMITION ELECTRON MICROSCOPIC STUDY OF THE EFFECTS OF BAX PROTEIN ON HEPATIC LYSOSOME AND ITS ROLE IN APOPTOSIS. PAJOUHESH-VA-SAZANDEGI[Internet]. 2004;17(1 (62 IN ANIMAL AND FISHERIES SCIENCES)):10-13. Available from: https://sid.ir/paper/19275/en

IEEE: Copy

A.R RAJI, and K. YAMACHITA, “A TRANSMITION ELECTRON MICROSCOPIC STUDY OF THE EFFECTS OF BAX PROTEIN ON HEPATIC LYSOSOME AND ITS ROLE IN APOPTOSIS,” PAJOUHESH-VA-SAZANDEGI, vol. 17, no. 1 (62 IN ANIMAL AND FISHERIES SCIENCES), pp. 10–13, 2004, [Online]. Available: https://sid.ir/paper/19275/en

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