Genome-wide analysis for detection of loci under positive selection in Zandi sheep breed

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MOHAMMADI HOSSEIN; RAFAT SEYED ABBAS; MORADI SHAHREBABAK HOSSEIN; Shodja Jalil; MORADI MOHAMAD HOSSEIN

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Journal: Iranian Journal of Animal Science Year:2018 | Volume:48 | Issue:4 Page(s): 533-548

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Title

Genome-wide analysis for detection of loci under positive selection in Zandi sheep breed

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Keywords

AdaptationQ1

genome scanQ1

iHS testQ1

selection signature detectionQ1

Abstract

Identification of selection targeted genomic regions is one of the main aims of biological research. The objective of this study was a genome-wide scan to identify the genomic regions that have been under artificial and natural selection in Zandi sheep breed. For this purpose, 96 animal of Zandi breed have been genotyped using the Illumina ovine SNP50 BeadChip. The intergrated hapl-type score (iHS) test was used to detect the selection sweep, due to linkage disequilibrium, associated with these signatures. The results revealed eleven genomic regions on 1 (two areas), 3, 6, 7, 8, 9, 10, 17, 22 and 26 chromosomes. Bioinformatics analysis demonstrated that some of these genomic regions overlapped with reported genes that directly and indirectly influenced traits for Adaptation to hot arid environments (DNAJB4, HSPA4L, MSRB3), immune response (IL23A, STAT6, LY96), body size and development (STAC3, LAP3), development of the skeletal system (SPP1, MEPE, IBSP) and energy and digestive metabolism (ATP5B, GLS2, CS). Finally, study of the reported QTL in these regions of the sheep genome showed that they overlapped with QTL of economically important traits such as carcass yield, growth and wool traits. However, it will be necessary to carry out more association and functional studies to demonstrate the implication of these genes.

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APA: Copy

MOHAMMADI, HOSSEIN, RAFAT, SEYED ABBAS, MORADI SHAHREBABAK, HOSSEIN, Shodja, Jalil, & MORADI, MOHAMAD HOSSEIN. (2018). Genome-wide analysis for detection of loci under positive selection in Zandi sheep breed. IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES), 48(4 ), 533-548. SID. https://sid.ir/paper/193493/en

Vancouver: Copy

MOHAMMADI HOSSEIN, RAFAT SEYED ABBAS, MORADI SHAHREBABAK HOSSEIN, Shodja Jalil, MORADI MOHAMAD HOSSEIN. Genome-wide analysis for detection of loci under positive selection in Zandi sheep breed. IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES)[Internet]. 2018;48(4 ):533-548. Available from: https://sid.ir/paper/193493/en

IEEE: Copy

HOSSEIN MOHAMMADI, SEYED ABBAS RAFAT, HOSSEIN MORADI SHAHREBABAK, Jalil Shodja, and MOHAMAD HOSSEIN MORADI, “Genome-wide analysis for detection of loci under positive selection in Zandi sheep breed,” IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES), vol. 48, no. 4 , pp. 533–548, 2018, [Online]. Available: https://sid.ir/paper/193493/en

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