THE STUDY OF ALPHA-TOCOPHEROL CYTOTOXICITY ON CANINE MAMMARY GLAND CANCER CELLS (CF41.MG) IN VITRO

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SEFIDABI R.; MORTAZAVI P.

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Paper Information

Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2015 | Volume:12 (NEW) | Issue:3 (50) Page(s): 1683-1690

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Title

THE STUDY OF ALPHA-TOCOPHEROL CYTOTOXICITY ON CANINE MAMMARY GLAND CANCER CELLS (CF41.MG) IN VITRO

Author(s)

SEFIDABI R. | MORTAZAVI P. | Issue Writer Certificate

Keywords

CYTOTOXICITYQ2

ALPHA-TOCOPHEROLQ2

MAMMARY GLAND CANCERQ2

CANINEQ2

Abstract

Breast cancer is the most common cause of cancer in female dogs. Created mutations in genes associated with cancer and oxidative modification of proteins and reactive aldehydes are key events that can increase cancer risk. The role of antioxidants in prevention and treatment of cancers have been reported by several studies. The aim of this study was to evaluate in vitro, the anti proliferative effect of ALPHA-TOCOPHEROL against CANINE mammary gland carcinoma cell line (CF41.Mg). CF41.Mg cells were cultured in RPMI 1640 medium. The cells were treated with different concentration of ALPHA-TOCOPHEROL for 24, 48 and 72 h. Anti proliferative effect of ALPHA-TOCOPHEROL was investigated using MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-tetrazolium bromide) assay. The results indicated that ALPHA-TOCOPHEROL inhibited proliferation of CANINE mammary gland carcinoma cells so that treatment with 100 micro M ALPHA-TOCOPHEROL for 72 h resulted in a significant decrease in cell viability. The ALPHA-TOCOPHEROL showed less effect after 48 h. The results of this study confirm the inhibitory effect of ALPHA-TOCOPHEROL on CANINE breast cancer cells (CF41.Mg).

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APA: Copy

SEFIDABI, R., & MORTAZAVI, P.. (2015). THE STUDY OF ALPHA-TOCOPHEROL CYTOTOXICITY ON CANINE MAMMARY GLAND CANCER CELLS (CF41.MG) IN VITRO. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 12 (NEW)(3 (50)), 1683-1690. SID. https://sid.ir/paper/197281/en

Vancouver: Copy

SEFIDABI R., MORTAZAVI P.. THE STUDY OF ALPHA-TOCOPHEROL CYTOTOXICITY ON CANINE MAMMARY GLAND CANCER CELLS (CF41.MG) IN VITRO. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2015;12 (NEW)(3 (50)):1683-1690. Available from: https://sid.ir/paper/197281/en

IEEE: Copy

R. SEFIDABI, and P. MORTAZAVI, “THE STUDY OF ALPHA-TOCOPHEROL CYTOTOXICITY ON CANINE MAMMARY GLAND CANCER CELLS (CF41.MG) IN VITRO,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 12 (NEW), no. 3 (50), pp. 1683–1690, 2015, [Online]. Available: https://sid.ir/paper/197281/en

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