THE ANTI- PROLIFERATIVE AND LETHAL EFFECTS OF D-ALPHA TOCOPHERYL SUCCINATE (VITAMIN E SUCCINATE) AND HONEY BEE VENOM(BV) ON HUMAN PROMYELOCYTE LEUKEMIA CELL LINE (HL-60)

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NABIUNI M.; YARAHMADI A.; DELFAN B.; MIRSEPASI S.; AZARI S.; GHOLAMI S.; RAMEZANI T.

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Journal: JOURNAL OF CELL & TISSUE Year:2013 | Volume:3 | Issue:4 Page(s): 287-296

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Title

THE ANTI- PROLIFERATIVE AND LETHAL EFFECTS OF D-ALPHA TOCOPHERYL SUCCINATE (VITAMIN E SUCCINATE) AND HONEY BEE VENOM(BV) ON HUMAN PROMYELOCYTE LEUKEMIA CELL LINE (HL-60)

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Keywords

ANTI- PROLIFERATIVEQ2

BEE VENOMQ3

HL-60 CELL LINEQ2

VITAMIN EQ2

Abstract

Aim: Acute promyelocytic leukemia is the most common leukemia among adults. Nowadays VITAMIN E has been used for cancer treatment in research and clinical approach. Application of high concentrations of VITAMIN E to induce apoptosis have side effects so in this study we examined the effect of BEE VENOM or VITAMIN E or both together on the induction of apoptosis in HL-60 CELL LINE in order to increase anti-proliferative ability and reduce side effect of VITAMIN E.Material and Methods: HL-60 CELL LINE were cultured in RPMI medium and then treated with different concentrations of VITAMIN E and BEE VENOM. The effect of BEE VENOM and VITAMIN E on cell viability and proliferation were measured by MTT assay and cell counting trypan blue staining. Data were analyzed using one-way ANOVA test and Instate 3 software.Result: Our results show that inhibitory effect of VITAMIN E increased dramatically in the presence of BEE VENOM. On this basis we suggest that non- toxic concentration of BEE VENOM can increase anti –proliferative activity of VITAMIN E on HL-60 cancer cells.Conclusion: Our result show that non-toxic concentration of BV can increase inhibitory effects of VITAMIN E and it make hope that BV can increases the anti-proliferative potential of vitamins in non-toxic concentration and concentration without side effects in the future.

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APA: Copy

NABIUNI, M., YARAHMADI, A., DELFAN, B., MIRSEPASI, S., AZARI, S., GHOLAMI, S., & RAMEZANI, T.. (2013). THE ANTI- PROLIFERATIVE AND LETHAL EFFECTS OF D-ALPHA TOCOPHERYL SUCCINATE (VITAMIN E SUCCINATE) AND HONEY BEE VENOM(BV) ON HUMAN PROMYELOCYTE LEUKEMIA CELL LINE (HL-60). JOURNAL OF CELL & TISSUE, 3(4), 287-296. SID. https://sid.ir/paper/189068/en

Vancouver: Copy

NABIUNI M., YARAHMADI A., DELFAN B., MIRSEPASI S., AZARI S., GHOLAMI S., RAMEZANI T.. THE ANTI- PROLIFERATIVE AND LETHAL EFFECTS OF D-ALPHA TOCOPHERYL SUCCINATE (VITAMIN E SUCCINATE) AND HONEY BEE VENOM(BV) ON HUMAN PROMYELOCYTE LEUKEMIA CELL LINE (HL-60). JOURNAL OF CELL & TISSUE[Internet]. 2013;3(4):287-296. Available from: https://sid.ir/paper/189068/en

IEEE: Copy

M. NABIUNI, A. YARAHMADI, B. DELFAN, S. MIRSEPASI, S. AZARI, S. GHOLAMI, and T. RAMEZANI, “THE ANTI- PROLIFERATIVE AND LETHAL EFFECTS OF D-ALPHA TOCOPHERYL SUCCINATE (VITAMIN E SUCCINATE) AND HONEY BEE VENOM(BV) ON HUMAN PROMYELOCYTE LEUKEMIA CELL LINE (HL-60),” JOURNAL OF CELL & TISSUE, vol. 3, no. 4, pp. 287–296, 2013, [Online]. Available: https://sid.ir/paper/189068/en

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