EXPERIMENTAL STUDY ON INHIBITORY EFFECT OF BRASSICA OLERACEA L. VAR. ITALIC (BROCCOLI) ETHANOLIC EXTRACT ON 4-NITROQUINOLINE-1-OXID -INDUCED ORAL CARCINOMA IN THE MICE

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MOHAJERI D.; AGHA MOHAMMADI J.

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Paper Information

Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2014 | Volume:11 (NEW) | Issue:2 (45) Page(s): 1311-1320

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Title

EXPERIMENTAL STUDY ON INHIBITORY EFFECT OF BRASSICA OLERACEA L. VAR. ITALIC (BROCCOLI) ETHANOLIC EXTRACT ON 4-NITROQUINOLINE-1-OXID -INDUCED ORAL CARCINOMA IN THE MICE

Author(s)

MOHAJERI D. | AGHA MOHAMMADI J. | Issue Writer Certificate

Keywords

BRASSICA OLERACEA L.Q1

4-NITROQUINOLINE-1-OXIDQ2

ORAL CARCINOGENESISQ2

MICEQ2

Abstract

Squamous cell carcinoma of the oral cavity is the most frequent cancer in the world. Cancer chemoprevention is using of natural, synthetic or biological substances to reverse or prevent the development of cancer. BRASSICA OLERACEA L. var. italica (broccoli) because of substantial quantities of isothiocyanates and polyphenolics has cancer protective properties. In this study, 60 male MICE were randomly allocated into four groups. Group 1 served as control and was given the basal diet and tap water without 4-NQO. MICE from Groups 2 to 4 assigned to receive 30 ppm 4-NQO in drinking water for 12 weeks. Simultaneously, the MICE of groups 3 and 4, received broccoli extract at the doses of 200 and 400 mg/kg respectively, 3 times per week. At the end of experiment, the MICE were euthanized and tissue specimens collected from tongues and routine sections were prepared. Microscopically, there were no pathological alterations in control MICE. Premalignant lesions appeared after 12 weeks of the last application of 4NQO in carcinogen groups. Administration of broccoli extract at both doses during the experiment caused a significant reduction in the frequency of tongue preneoplasms. The incidences of tongue severe dysplasia in the high dose group was significantly smaller than the low dose group (p<0.05). The results obtained showed, broccoli is effective in prohibition of progress of oral cavity mucosa induced by 4-NITROQUINOLINE-1-OXID.

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APA: Copy

MOHAJERI, D., & AGHA MOHAMMADI, J.. (2014). EXPERIMENTAL STUDY ON INHIBITORY EFFECT OF BRASSICA OLERACEA L. VAR. ITALIC (BROCCOLI) ETHANOLIC EXTRACT ON 4-NITROQUINOLINE-1-OXID -INDUCED ORAL CARCINOMA IN THE MICE. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 11 (NEW)(2 (45)), 1311-1320. SID. https://sid.ir/paper/197431/en

Vancouver: Copy

MOHAJERI D., AGHA MOHAMMADI J.. EXPERIMENTAL STUDY ON INHIBITORY EFFECT OF BRASSICA OLERACEA L. VAR. ITALIC (BROCCOLI) ETHANOLIC EXTRACT ON 4-NITROQUINOLINE-1-OXID -INDUCED ORAL CARCINOMA IN THE MICE. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2014;11 (NEW)(2 (45)):1311-1320. Available from: https://sid.ir/paper/197431/en

IEEE: Copy

D. MOHAJERI, and J. AGHA MOHAMMADI, “EXPERIMENTAL STUDY ON INHIBITORY EFFECT OF BRASSICA OLERACEA L. VAR. ITALIC (BROCCOLI) ETHANOLIC EXTRACT ON 4-NITROQUINOLINE-1-OXID -INDUCED ORAL CARCINOMA IN THE MICE,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 11 (NEW), no. 2 (45), pp. 1311–1320, 2014, [Online]. Available: https://sid.ir/paper/197431/en

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