STABILITY STUDY OF REV1 REDUCED DOSE BRUCELLOSIS VACCINE PRODUCED BY RAZI INSTITUTE IN IRAN

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DOSTDARI S.; HASSANNYA E.; KHAFRI A.; EMADI A.; BAGHERINEJAD A.; ALAMYAN S.; BAGHERI SH.

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Journal Paper

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Journal: Veterinary Research & Biological Products Year:2017 | Volume:30 | Issue:3 (116) Page(s): 26-33

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Information Journal Paper

Title

STABILITY STUDY OF REV1 REDUCED DOSE BRUCELLOSIS VACCINE PRODUCED BY RAZI INSTITUTE IN IRAN

Author(s)

Keywords

STABILITYQ2

BRUCELLOSISQ2

REV.1 VACCINEQ1

Abstract

STABILITY study of biological products plays an important role for determination of product changes in maintenance period and ensuring of safety and efficacy of vaccines. In this study longterm STABILITY reduced-dose Rev.1 strain BRUCELLOSIS vaccin that manufactured by Razi vaccine and serum research institute was evaluated. Sampling was conducted in accordance with references OIE 2015, and the samples after storage at 8-2 oC and packaging conditions for 11 months, according to the vaccine package insert an interval of one month was tested for STABILITY Real time. In this study, all tests quality control and physicochemical tests for evaluate the STABILITY the vaccine for every 3 batches to 11 months after production was performed. For analyzing information from median, mean, variance, correlation and linear regression were used. The results of the study showed that all batches of studied, stable for 10 months in accordance with the requirements OIE 2015. If the conditions that all the requirements related to the preservation of vaccine including cold chain conditions should be observed. The vaccine can be stable for 10 months. Therefore, in accordance with the requirements OIE 2015, BP 2015 the expiration date of the vaccine can be increased from 4 months to 7 months.

Cites

Evaluation of Humoral Immune Responses of Sheep Vaccinated With Razi Institute Rev. 1 Brucellosis Vaccine in Comparison to a Spanish (CZV) Rev. 1 Vaccine

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APA: Copy

DOSTDARI, S., HASSANNYA, E., KHAFRI, A., EMADI, A., BAGHERINEJAD, A., ALAMYAN, S., & BAGHERI, SH.. (2017). STABILITY STUDY OF REV1 REDUCED DOSE BRUCELLOSIS VACCINE PRODUCED BY RAZI INSTITUTE IN IRAN. VETERINARY RESEARCHES BIOLOGICAL PRODUCTS (PAJOUHESH-VA-SAZANDEGI), 30(3 (116)), 26-33. SID. https://sid.ir/paper/200859/en

Vancouver: Copy

DOSTDARI S., HASSANNYA E., KHAFRI A., EMADI A., BAGHERINEJAD A., ALAMYAN S., BAGHERI SH.. STABILITY STUDY OF REV1 REDUCED DOSE BRUCELLOSIS VACCINE PRODUCED BY RAZI INSTITUTE IN IRAN. VETERINARY RESEARCHES BIOLOGICAL PRODUCTS (PAJOUHESH-VA-SAZANDEGI)[Internet]. 2017;30(3 (116)):26-33. Available from: https://sid.ir/paper/200859/en

IEEE: Copy

S. DOSTDARI, E. HASSANNYA, A. KHAFRI, A. EMADI, A. BAGHERINEJAD, S. ALAMYAN, and SH. BAGHERI, “STABILITY STUDY OF REV1 REDUCED DOSE BRUCELLOSIS VACCINE PRODUCED BY RAZI INSTITUTE IN IRAN,” VETERINARY RESEARCHES BIOLOGICAL PRODUCTS (PAJOUHESH-VA-SAZANDEGI), vol. 30, no. 3 (116), pp. 26–33, 2017, [Online]. Available: https://sid.ir/paper/200859/en

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