Study on antibacterial activity and cytotoxicity of recombinant peptide, Lasioglossin ɪ ɪ ɪ , against foodborne pathogens

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HABIBI NAJAFI M.B.; Tanhaian a.; RAHNAMA P.; AZGHANDI M.

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Journal: JOURNAL OF AGRICULTURAL BIOTECHNOLOGY Year:2018 | Volume:10 | Issue:3 Page(s): 31-44

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Title

Study on antibacterial activity and cytotoxicity of recombinant peptide, Lasioglossin ɪ ɪ ɪ , against foodborne pathogens

Author(s)

HABIBI NAJAFI M.B. | Tanhaian a. | RAHNAMA P. | AZGHANDI M. | Issue Writer Certificate

Keywords

Lasioglossin ɪɪɪQ1

Antimicrobial peptideQ1

cytotoxicityQ1

food pathogenQ1

Abstract

The increasing microbial resistance to existing antibiotics has increased the interest in novel antimicrobial compounds. Antimicrobial peptides (AMPs) represent an attractive alternative to classical antibiotics. Lasioglossins are a group of peptides with antimicrobial activity. The inhibitory effects of a recombinant synthetic Lasioglossin, Lasioglossin ɪ ɪ ɪ , on five food pathogens (Staphylococcus aureus, Salmonella typhimurium, Enterococcus faecalis, Listeria monocytogenes and Escherichia coli) and its cytotoxicity on the normal cell line was investigated in vitro. The findings showed great antimicrobial function of the peptide. Minimum inhibition concentration and minimum bactericidal concentration of Lasioglossin ɪ ɪ ɪ on the pathogens were the range of 3. 851-8. 625 and 7. 703-15. 406, respectively. Results indicated Staphylococcus aureus showed the highest sensitivity to Lasioglossin ɪ ɪ ɪ . The Lassioglossin demonstrated cytotoxic effect on human embryonic kidney cells in higher concentration (1652 μ g/ml) in comparison to MIC and MBC values. The results indicate that this peptide can be competed with common antibiotics in terms of the bactericidal properties.

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APA: Copy

HABIBI NAJAFI, M.B., Tanhaian, a., RAHNAMA, P., & AZGHANDI, M.. (2018). Study on antibacterial activity and cytotoxicity of recombinant peptide, Lasioglossin ɪ ɪ ɪ , against foodborne pathogens. JOURNAL OF AGRICULTURAL BIOTECHNOLOGY, 10(3 ), 31-44. SID. https://sid.ir/paper/224419/en

Vancouver: Copy

HABIBI NAJAFI M.B., Tanhaian a., RAHNAMA P., AZGHANDI M.. Study on antibacterial activity and cytotoxicity of recombinant peptide, Lasioglossin ɪ ɪ ɪ , against foodborne pathogens. JOURNAL OF AGRICULTURAL BIOTECHNOLOGY[Internet]. 2018;10(3 ):31-44. Available from: https://sid.ir/paper/224419/en

IEEE: Copy

M.B. HABIBI NAJAFI, a. Tanhaian, P. RAHNAMA, and M. AZGHANDI, “Study on antibacterial activity and cytotoxicity of recombinant peptide, Lasioglossin ɪ ɪ ɪ , against foodborne pathogens,” JOURNAL OF AGRICULTURAL BIOTECHNOLOGY, vol. 10, no. 3 , pp. 31–44, 2018, [Online]. Available: https://sid.ir/paper/224419/en

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