DETERMINATION OF THE DIAGNOSTIC VALUE OF POSITIVE AND NEGATIVE ACUTE PHASE PROTEINS OF THE MILK AS NEW AND RELIABLE BIOMARKERS IN BOVINE SUBCLINICAL MASTITIS

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SHIRAZI BEHESHTIHA S.H.; RABBANI V.; SAFI S.; BOLOURCHI M.; AMERI M.

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Journal: JOURNAL OF VETERINARY CLINICAL RESEARCH Year:2011 | Volume:2 | Issue:2 (6) Page(s): 74-87

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Title

DETERMINATION OF THE DIAGNOSTIC VALUE OF POSITIVE AND NEGATIVE ACUTE PHASE PROTEINS OF THE MILK AS NEW AND RELIABLE BIOMARKERS IN BOVINE SUBCLINICAL MASTITIS

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Keywords

ACUTE PHASE PROTEINSQ2

BIOMARKERQ2

SUBCLINICAL MASTITISQ2

MILKQ2

BOVINEQ3

Abstract

Currently, somatic cell count (SCC) and bacterial culture is considered as the golden and ultimate standard methods for diagnosis of BOVINE SUBCLINICAL MASTITIS. However, SCC has a low diagnostic accuracy. Therefore, for identification of infected animals new BIOMARKERs with high diagnostic accuracy are needed. ACUTE PHASE PROTEINS (APPs) are proteins that are increased (positive APPs) or decreased (negative APPs) in response to inflammation.The objective of this study was to determine the diagnostic value of the MILK APPs for the diagnosis of SUBCLINICAL MASTITIS in dairy cows. A total of 90 clinically healthy cows were randomly selected. Of these, 52 cows were considered to have SUBCLINICAL MASTITIS based on a SCC higher than 130×1000 cells/mL of MILK and positive bacterial culture results of MILK samples obtained from at least one of the quarters. MILK amyloid A (MAA) concentration was measured using a commercial ELISA kit and albumin, a-lactalbumin, b-lactoglobulin, and immunoglobulin (Ig) were measured in whey samples by using cellulose acetate electrophoresis. Diagnostic sensitivity and specificity and cutoff points for each test were determined via receiver-operating characteristics (ROC) analysis. Significant (P<0.001) increases in the mean and median concentration of MAA, albumin, a-lactalbumin, and Ig were found in the MILK samples collected from cows with SUBCLINICAL MASTITIS. MAA was the most accurate test with a diagnostic sensitivity of 92.3% and specificity of 92.1% at cutoff point of>1.6 mg/L. The results of this study showed that determination of MAA and some MILK serum proteins such as albumin and immunoglobulins can be used as potential and reliable BIOMARKERs for the diagnosis of BOVINE SUBCLINICAL MASTITIS.

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APA: Copy

SHIRAZI BEHESHTIHA, S.H., RABBANI, V., SAFI, S., BOLOURCHI, M., & AMERI, M.. (2011). DETERMINATION OF THE DIAGNOSTIC VALUE OF POSITIVE AND NEGATIVE ACUTE PHASE PROTEINS OF THE MILK AS NEW AND RELIABLE BIOMARKERS IN BOVINE SUBCLINICAL MASTITIS. JOURNAL OF VETERINARY CLINICAL RESEARCH, 2(2 (6)), 74-87. SID. https://sid.ir/paper/233058/en

Vancouver: Copy

SHIRAZI BEHESHTIHA S.H., RABBANI V., SAFI S., BOLOURCHI M., AMERI M.. DETERMINATION OF THE DIAGNOSTIC VALUE OF POSITIVE AND NEGATIVE ACUTE PHASE PROTEINS OF THE MILK AS NEW AND RELIABLE BIOMARKERS IN BOVINE SUBCLINICAL MASTITIS. JOURNAL OF VETERINARY CLINICAL RESEARCH[Internet]. 2011;2(2 (6)):74-87. Available from: https://sid.ir/paper/233058/en

IEEE: Copy

S.H. SHIRAZI BEHESHTIHA, V. RABBANI, S. SAFI, M. BOLOURCHI, and M. AMERI, “DETERMINATION OF THE DIAGNOSTIC VALUE OF POSITIVE AND NEGATIVE ACUTE PHASE PROTEINS OF THE MILK AS NEW AND RELIABLE BIOMARKERS IN BOVINE SUBCLINICAL MASTITIS,” JOURNAL OF VETERINARY CLINICAL RESEARCH, vol. 2, no. 2 (6), pp. 74–87, 2011, [Online]. Available: https://sid.ir/paper/233058/en

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