DRUG LOADING AND RELEASE BEHAVIOR OF GRAPHENE OXIDE/MAGNETITE NANOCOMPOSITE

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FARAZI REYHANEH; VAEZI MOHAMMAD REZA; MOLAEI MOHAMMAD JAFAR; SAEIDIFAR MARYAM

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Journal: JOURNAL OF ADVANCED MATERIALS AND TECHNOLOGIES Year:2017 | Volume:6 | Issue:1 Page(s): 33-41

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Information Journal Paper

Title

DRUG LOADING AND RELEASE BEHAVIOR OF GRAPHENE OXIDE/MAGNETITE NANOCOMPOSITE

Author(s)

FARAZI REYHANEH | VAEZI MOHAMMAD REZA | MOLAEI MOHAMMAD JAFAR | SAEIDIFAR MARYAM | Issue Writer Certificate

Keywords

GRAPHENE OXIDEQ1

MAGNETITEQ2

SUPERPARAMAGNETICQ2

DRUG DELIVERYQ2

DOXORUBICIN HYDROCHLORIDEQ2

Abstract

Graphene based materials such as GRAPHENE OXIDE have been developed in the biomedical applications during recent years. In this research, GRAPHENE OXIDE/magnetite nanocomposite with drug controlled release ability was synthesized through coprecipitation on GRAPHENE OXIDE sheets. Phase analysis, particles morphology, magnetic properties, drug loading and release behavior of the synthesized nanocomposite was investigated using XRD, FESEM, VSM and UV-visible spectroscopy, respectively. XRD pattern showed formation of the GRAPHENE OXIDE/magnetite nanocomposite. FESEM images revealed that the mean particles size is 14 nm. The synthesized nanocomposite showed SUPERPARAMAGNETIC characteristics while the saturation magnetization of the nanocomposite was 47 emu/g. DOXORUBICIN HYDROCHLORIDE as an anti-cancer drug was loaded on the nanocomposite. Encapsulation efficiency and loading of the drug for the nanocomposite were 51.76% and 34.68%, respectively. The release model of the drug was best matched with Korsmeyer-Peppas model.

Cites

Evaluation of Biocompatibility and Release Profile of Ginger Extract Loaded Hyaluronic Acid Nanocapsules for Medical Applications

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APA: Copy

FARAZI, REYHANEH, VAEZI, MOHAMMAD REZA, MOLAEI, MOHAMMAD JAFAR, & SAEIDIFAR, MARYAM. (2017). DRUG LOADING AND RELEASE BEHAVIOR OF GRAPHENE OXIDE/MAGNETITE NANOCOMPOSITE. JOURNAL OF ADVANCED MATERIALS AND TECHNOLOGIES, 6(1 ), 33-41. SID. https://sid.ir/paper/252453/en

Vancouver: Copy

FARAZI REYHANEH, VAEZI MOHAMMAD REZA, MOLAEI MOHAMMAD JAFAR, SAEIDIFAR MARYAM. DRUG LOADING AND RELEASE BEHAVIOR OF GRAPHENE OXIDE/MAGNETITE NANOCOMPOSITE. JOURNAL OF ADVANCED MATERIALS AND TECHNOLOGIES[Internet]. 2017;6(1 ):33-41. Available from: https://sid.ir/paper/252453/en

IEEE: Copy

REYHANEH FARAZI, MOHAMMAD REZA VAEZI, MOHAMMAD JAFAR MOLAEI, and MARYAM SAEIDIFAR, “DRUG LOADING AND RELEASE BEHAVIOR OF GRAPHENE OXIDE/MAGNETITE NANOCOMPOSITE,” JOURNAL OF ADVANCED MATERIALS AND TECHNOLOGIES, vol. 6, no. 1 , pp. 33–41, 2017, [Online]. Available: https://sid.ir/paper/252453/en

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