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Information Journal Paper

Title

ALTERATIONS OF METABOLIC PROFILE OF HOLSTEIN DAIRY CALVES FOLLOWING THE INTRAMUSCULAR ADMINISTRATION OF DEXAMETHASONE AND ISOFLUPREDONE

Pages

  71-78

Abstract

 Glucocorticoids have been used in large animal medicine for treating several disorders. But besides their therapeutic advantages, they have different side effects. METABOLIC DISTURBANCEs may be considered important following the administration of GLUCOCORTICOIDS because of their disadvantage in large animal medicine. Ten clinically healthy HOLSTEIN CALVES (6-8 months old) were assigned into 2 equal groups. Dexamethasone and isoflupredone were administered in each group separately at 1 mg/kg, on two consecutive days. Blood samples were taken at days 0 (1st drug administration), 1 (2nd drug administration), 2, 3, 5 and 7, from all studied animals. Glucose, β-hydroxybutyric acid, nonesterified fatty acid, cholesterol, triglyceride and high, low and very low density lipoprotein concentrations were detected in separated sera. All studied metabolic biomarkers significantly increased after both drugs administrations (P<0.05). The concentrations of circulating metabolic biomarkers in isoflupredone treated group were significantly higher than the other one (P<0.05).Dexamethasone and isoflupredone can interfere with metabolic pathways by several mechanisms in HOLSTEIN CALVES. The data presented here can aid veterinarians to make better decision on using the glucocrticoids in large animal medicine.

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    APA: Copy

    CHALMEH, A., POURJAFAR, M., NAZIFI, S., & ZAREI, M.R.. (2017). ALTERATIONS OF METABOLIC PROFILE OF HOLSTEIN DAIRY CALVES FOLLOWING THE INTRAMUSCULAR ADMINISTRATION OF DEXAMETHASONE AND ISOFLUPREDONE. IRANIAN JOURNAL OF VETERINARY CLINICAL SCIENCES, 11(1), 71-78. SID. https://sid.ir/paper/260125/en

    Vancouver: Copy

    CHALMEH A., POURJAFAR M., NAZIFI S., ZAREI M.R.. ALTERATIONS OF METABOLIC PROFILE OF HOLSTEIN DAIRY CALVES FOLLOWING THE INTRAMUSCULAR ADMINISTRATION OF DEXAMETHASONE AND ISOFLUPREDONE. IRANIAN JOURNAL OF VETERINARY CLINICAL SCIENCES[Internet]. 2017;11(1):71-78. Available from: https://sid.ir/paper/260125/en

    IEEE: Copy

    A. CHALMEH, M. POURJAFAR, S. NAZIFI, and M.R. ZAREI, “ALTERATIONS OF METABOLIC PROFILE OF HOLSTEIN DAIRY CALVES FOLLOWING THE INTRAMUSCULAR ADMINISTRATION OF DEXAMETHASONE AND ISOFLUPREDONE,” IRANIAN JOURNAL OF VETERINARY CLINICAL SCIENCES, vol. 11, no. 1, pp. 71–78, 2017, [Online]. Available: https://sid.ir/paper/260125/en

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