Effects of L-carnitine and betamethasone on ischemia-reperfusion injuries and sperm parameters following testicular torsion in a rat model

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KAZEMI DARABADI SIAMAK; ASADPOUR REZA; SHAHBAZFAR AMIR ALI; ALIZADEH SAJJAD

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Journal: VETERINARY RESEARCH FORUM Year:2019 | Volume:10 | Issue:2 Page(s): 125-132

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Title

Effects of L-carnitine and betamethasone on ischemia-reperfusion injuries and sperm parameters following testicular torsion in a rat model

Author(s)

KAZEMI DARABADI SIAMAK | ASADPOUR REZA | SHAHBAZFAR AMIR ALI | ALIZADEH SAJJAD | Issue Writer Certificate

Keywords

BetamethasoneQ1

CarnitineQ1

Reperfusion injuryQ1

Spermatic cord torsionQ1

Sperm characteristicsQ1

Abstract

Testicular torsion is a consequence of spermatic cord twisting which causes progressive damage to the structure of the testis and reduces sperm quality and usually results in infertility. In the present study, with the assumption of the protective effects of L-Carnitine and Betamethasone against ischemia-reperfusion (IR) injuries, their effects on twisted testicles were evaluated and compared. Twenty Wistar rats were randomly divided into four groups and used in this study. Except for the Sham (S) group, testicular IR was induced surgically in three other groups, including Control (C), Betamethasone (BM), and L-Carnitine (LC) groups. Betamethasone and L-Carnitine were injected before detorsion in the BM and LC groups, respectively. After twelve hours of reperfusion, the testicles were detached, and prepared for sperm parameters evaluation such as sperm count, motility, viability, morphology, and chromatin quality, and histopathologic evaluations, including mean seminiferous tubular diameter (MSTD), germinal epithelial cell thickness (GECT), and Johnsen’ s mean testicular biopsy scoring (MTBS). The MSTD, GECT, and healthy sperms in the C group were significantly lower than the other groups, while the BM and LC groups were significantly different from others in MTBS. The number of sperms and sperm motility in the BM group was significantly higher than the C group. Sperm viability in the BM and LC groups were significantly higher than the C group. The results of this study showed that both L-Carnitine and Betamethasone similarly can be effective in treating testicular IR injuries.

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APA: Copy

KAZEMI DARABADI, SIAMAK, ASADPOUR, REZA, SHAHBAZFAR, AMIR ALI, & ALIZADEH, SAJJAD. (2019). Effects of L-carnitine and betamethasone on ischemia-reperfusion injuries and sperm parameters following testicular torsion in a rat model. VETERINARY RESEARCH FORUM, 10(2 ), 125-132. SID. https://sid.ir/paper/263603/en

Vancouver: Copy

KAZEMI DARABADI SIAMAK, ASADPOUR REZA, SHAHBAZFAR AMIR ALI, ALIZADEH SAJJAD. Effects of L-carnitine and betamethasone on ischemia-reperfusion injuries and sperm parameters following testicular torsion in a rat model. VETERINARY RESEARCH FORUM[Internet]. 2019;10(2 ):125-132. Available from: https://sid.ir/paper/263603/en

IEEE: Copy

SIAMAK KAZEMI DARABADI, REZA ASADPOUR, AMIR ALI SHAHBAZFAR, and SAJJAD ALIZADEH, “Effects of L-carnitine and betamethasone on ischemia-reperfusion injuries and sperm parameters following testicular torsion in a rat model,” VETERINARY RESEARCH FORUM, vol. 10, no. 2 , pp. 125–132, 2019, [Online]. Available: https://sid.ir/paper/263603/en

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