Co-administration of retinoic acid and atorvastatin mitigates high-fat diet induced renal damage in rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ZAREI LEILA; Mahdavi Rad Saied; ABDOLLAHZADE FARD AMIN

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: VETERINARY RESEARCH FORUM Year:2019 | Volume:10 | Issue:2 Page(s): 133-138

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

526

Download:

161

Cites:

Information Journal Paper

Title

Co-administration of retinoic acid and atorvastatin mitigates high-fat diet induced renal damage in rats

Author(s)

ZAREI LEILA | Mahdavi Rad Saied | ABDOLLAHZADE FARD AMIN | Issue Writer Certificate

Keywords

AtorvastatinQ1

High-fat dietQ1

Protein carbonylQ1

Retinoic acidQ1

Abstract

Obesity causes many problems such as cardiovascular and chronic kidney diseases. The aim of this study was to evaluate the efficacy of Retinoic acid and Atorvastatin co-administration in kidneys protection against High-fat diet induced damage. Twenty-five male Wistar rats (200. 00 ± 20. 00 g) were divided into five groups: 1) Control (standard diet), 2) High-fat diet (cholesterol 1. 00%, 75 days), 3) High-fat diet + Atorvastatin (20. 00 mg kg-1 per day, orally, on the 30th day, for 45 consecutive days), 4) High-fat diet + Retinoic acid (5 mg kg-1 per day, orally, on the 30th day, for 45 consecutive days), and 5) High fat diet + Atorvastatin and Retinoic acid. At the end, blood and tissue samples were collected for biochemical and histological analyses. The results showed that Atorvastatin and Retinoic acid alone and in combination decreased cholesterol and low-density lipoprotein and increased high-density lipoprotein in High-fat diet. Also, Atorvastatin – caused total antioxidant capacity increase and Protein carbonyl content decrease the in the renal tissue. Atorvastatin also prevented High-fat diet-induced renal histological injury. Treatment with Atorvastatin significantly mitigates High-fat diet-induced renal changes probably due to its potent antioxidant and lipid-lowering effects. The effect of Retinoic acid in renal protection in a High-fat diet is far less than that of Atorvastatin. The protective effect of the combination of these two agents in the High-fat diet on the kidneys seems to be due to the effect of Atorvastatin.

Cites

No record.

References

No record.

Cite

APA: Copy

ZAREI, LEILA, Mahdavi Rad, Saied, & ABDOLLAHZADE FARD, AMIN. (2019). Co-administration of retinoic acid and atorvastatin mitigates high-fat diet induced renal damage in rats. VETERINARY RESEARCH FORUM, 10(2 ), 133-138. SID. https://sid.ir/paper/263607/en

Vancouver: Copy

ZAREI LEILA, Mahdavi Rad Saied, ABDOLLAHZADE FARD AMIN. Co-administration of retinoic acid and atorvastatin mitigates high-fat diet induced renal damage in rats. VETERINARY RESEARCH FORUM[Internet]. 2019;10(2 ):133-138. Available from: https://sid.ir/paper/263607/en

IEEE: Copy

LEILA ZAREI, Saied Mahdavi Rad, and AMIN ABDOLLAHZADE FARD, “Co-administration of retinoic acid and atorvastatin mitigates high-fat diet induced renal damage in rats,” VETERINARY RESEARCH FORUM, vol. 10, no. 2 , pp. 133–138, 2019, [Online]. Available: https://sid.ir/paper/263607/en

Related Journal Papers