Effect of atorvastatin on spatial memory in high-fat dietary rats

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Nosrati Mohammad; SEPEHRI HAMID

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Journal: Journal of Gorgan University of Medical Sciences Year:2019 | Volume:21 | Issue:1 (69) Page(s): 23-30

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Title

Effect of atorvastatin on spatial memory in high-fat dietary rats

Author(s)

Nosrati Mohammad | SEPEHRI HAMID | Issue Writer Certificate

Keywords

AtorvastatinQ2

Spatial memoryQ2

Morris Water MazeQ2

High-fat dietQ1

RatQ2

Abstract

Background and Objective: Atorvastatin is a member of the statin family with lipophilic character and anti-hyperlipidemic effect. There is many evidence that Atorvastatin has protective effect on cognitive function. This study was done to evaluate the effect of Atorvastatin on Spatial memory in Rats following a High-fat diet. Methods: This experimental study was performed on 35 male Wistar male Rats. Animals were randomly allocated into 5 groups including control, control plus Atorvastatin and sham (received High-fat diet for 4 weeks) and High-fat diet plus Atorvastatin (10 and 50 mg/kg, for 4 weeks). Learning and Spatial memory were measured using Morris Water Maze for a 6-day period including 5 days training and the last day, test day (probe day). Results: High-fat diet reduced learning and poor memory performance during training and probe compared to the control group, and also on the probe day, the high-fat group spent less time in the target quarter (P<0. 05). AdministRation of Atorvastatin after a High-fat diet improvement Spatial memory in compared to high-fat group (P<0. 05). Conclusion: Short-term treatment (4 weeks) with Atorvastatin in High-fat dietary Rats can improve Spatial memory.

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APA: Copy

Nosrati, Mohammad, & SEPEHRI, HAMID. (2019). Effect of atorvastatin on spatial memory in high-fat dietary rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 21(1 (69) ), 23-30. SID. https://sid.ir/paper/406332/en

Vancouver: Copy

Nosrati Mohammad, SEPEHRI HAMID. Effect of atorvastatin on spatial memory in high-fat dietary rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;21(1 (69) ):23-30. Available from: https://sid.ir/paper/406332/en

IEEE: Copy

Mohammad Nosrati, and HAMID SEPEHRI, “Effect of atorvastatin on spatial memory in high-fat dietary rats,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 1 (69) , pp. 23–30, 2019, [Online]. Available: https://sid.ir/paper/406332/en

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