FLORFENICOL PHARMACOKINETICS FOLLOWING INTRAVENOUS AND ORAL ADMINISTRATIONS AND ITS ELIMINATION AFTER ORAL AND BATH ADMINISTRATIONS IN COMMON CARP (CYPRINUS CARPIO)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JANGARAN NEJAD ABDOLHOSSEIN; PEYGHAN RAHIM; NAJAFZADEH VARZI HOSSEIN; SHAHRIYARI ALI

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: VETERINARY RESEARCH FORUM Year:2017 | Volume:8 | Issue:4 Page(s): 327-331

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

653

Download:

197

Cites:

Information Journal Paper

Title

FLORFENICOL PHARMACOKINETICS FOLLOWING INTRAVENOUS AND ORAL ADMINISTRATIONS AND ITS ELIMINATION AFTER ORAL AND BATH ADMINISTRATIONS IN COMMON CARP (CYPRINUS CARPIO)

Author(s)

JANGARAN NEJAD ABDOLHOSSEIN | PEYGHAN RAHIM | NAJAFZADEH VARZI HOSSEIN | SHAHRIYARI ALI | Issue Writer Certificate

Keywords

ANTIBIOTICQ1

COMMON CARP FLORFENICOLQ2

PHARMACOKINETICSQ2

Abstract

The aim of this study was to evaluate pharmacokinetic profiles of florfenicol after a single dose of intravenous (5.00 mg kg-1 body weight) and oral (40.00 mg kg-1 body weight) administrations in common carp (Cyprinus carpio). The residue depletion of florfenicol was also investigated after oral administration (10.00 mg kg-1 body weight) and bath treatment (5.00 mg L-1) for 10 consecutive days. PHARMACOKINETICS of florfenicol in plasma after a single dose administration, at 10 time points (0.50, 1, 2, 4, 8, 12, 24, 72, 120 and 168 hr) and florfenicol concentrations in tissues (plasma, liver and muscle) at three time points (1, 7 and 14 days) after 10 consecutive days, were analyzed by high performance liquid chromatography. The peak concentration of florfenicol was 137.02 ng mL-1 and the time to reach peak concentration in plasma was two hr. The elimination half-lives, the volume of distribution at steady state and total body clearance were estimated as 21.40 hr, 0.30 and 0.03 L hr-1, respectively. After drug administration for 10 days, it's concentration in plasma and muscle in oral treatment was significantly more than bath treatment in all days. Drug concentrations in the liver after bath treatment were significantly higher for a shorter period than the concentration in the oral treatment, indicating that higher levels of florfenicol for a longer period can be achieved in the tissues after oral drug administration. According to pharmacokinetic results, florfenicol may be a suitable candidate for the treatment of common bacterial infections in common carp farming.

Cites

No record.

References

No record.

Cite

APA: Copy

JANGARAN NEJAD, ABDOLHOSSEIN, PEYGHAN, RAHIM, NAJAFZADEH VARZI, HOSSEIN, & SHAHRIYARI, ALI. (2017). FLORFENICOL PHARMACOKINETICS FOLLOWING INTRAVENOUS AND ORAL ADMINISTRATIONS AND ITS ELIMINATION AFTER ORAL AND BATH ADMINISTRATIONS IN COMMON CARP (CYPRINUS CARPIO). VETERINARY RESEARCH FORUM, 8(4 ), 327-331. SID. https://sid.ir/paper/263636/en

Vancouver: Copy

JANGARAN NEJAD ABDOLHOSSEIN, PEYGHAN RAHIM, NAJAFZADEH VARZI HOSSEIN, SHAHRIYARI ALI. FLORFENICOL PHARMACOKINETICS FOLLOWING INTRAVENOUS AND ORAL ADMINISTRATIONS AND ITS ELIMINATION AFTER ORAL AND BATH ADMINISTRATIONS IN COMMON CARP (CYPRINUS CARPIO). VETERINARY RESEARCH FORUM[Internet]. 2017;8(4 ):327-331. Available from: https://sid.ir/paper/263636/en

IEEE: Copy

ABDOLHOSSEIN JANGARAN NEJAD, RAHIM PEYGHAN, HOSSEIN NAJAFZADEH VARZI, and ALI SHAHRIYARI, “FLORFENICOL PHARMACOKINETICS FOLLOWING INTRAVENOUS AND ORAL ADMINISTRATIONS AND ITS ELIMINATION AFTER ORAL AND BATH ADMINISTRATIONS IN COMMON CARP (CYPRINUS CARPIO),” VETERINARY RESEARCH FORUM, vol. 8, no. 4 , pp. 327–331, 2017, [Online]. Available: https://sid.ir/paper/263636/en

Related Journal Papers