Numerical Simulation of Hollow Fiber Membrane Bioreactor and Investigation of the Parameters Related to Animal Cells Culture

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Valadbeigy Sohrab; GHALICHI FARZAN; YEGANI REZA; AKBARI ALI

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Paper Information

Journal: JOURNAL OF MECHANICAL ENGINEERING Year:2020 | Volume:49 | Issue:4 (89) Page(s): 289-298

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Title

Numerical Simulation of Hollow Fiber Membrane Bioreactor and Investigation of the Parameters Related to Animal Cells Culture

Author(s)

Valadbeigy Sohrab | GHALICHI FARZAN | YEGANI REZA | AKBARI ALI | Issue Writer Certificate

Keywords

Hollow Fiber Membrane Bioreactor

Tissue Engineering

Animal cell culture

3D modeling

Computational Fluid Dynamics (CFD)

Abstract

Tissue Engineering and Animal cell culture have received considerable interest over the last few decades. Hollow Fiber Membrane Bioreactor is one of the most modern and efficient type of bioreactors. In the present paper, four hollow fibers inside a bioreactor are simulated using ANSYS FLUENT software package and their effects on the cell environment were studied. In order to optimum design and predict of membrane bioreactor, the flow parameters and concentration distribution of important metabolites such as oxygen and glucose were studied. Investigation the effect of cell concentration and distance from inlet on oxygen and glucose concentrations showed that at high cell concentrations (2×108 cells/ml), by increasing the distance from inlet, caused to decrease the glucose and oxygen concentrations, considerably. Also, increasing the inlet velocity caused to increase the oxygen and glucose concentrations inside the bioreactor. The obtained results from investigation of the bioreactor lengths showed that the glucose and oxygen concentrations did not change along the fibers in different distances from inlet.

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APA: Copy

Valadbeigy, Sohrab, GHALICHI, FARZAN, YEGANI, REZA, & AKBARI, ALI. (2020). Numerical Simulation of Hollow Fiber Membrane Bioreactor and Investigation of the Parameters Related to Animal Cells Culture. JOURNAL OF MECHANICAL ENGINEERING, 49(4 (89) ), 289-298. SID. https://sid.ir/paper/269887/en

Vancouver: Copy

Valadbeigy Sohrab, GHALICHI FARZAN, YEGANI REZA, AKBARI ALI. Numerical Simulation of Hollow Fiber Membrane Bioreactor and Investigation of the Parameters Related to Animal Cells Culture. JOURNAL OF MECHANICAL ENGINEERING[Internet]. 2020;49(4 (89) ):289-298. Available from: https://sid.ir/paper/269887/en

IEEE: Copy

Sohrab Valadbeigy, FARZAN GHALICHI, REZA YEGANI, and ALI AKBARI, “Numerical Simulation of Hollow Fiber Membrane Bioreactor and Investigation of the Parameters Related to Animal Cells Culture,” JOURNAL OF MECHANICAL ENGINEERING, vol. 49, no. 4 (89) , pp. 289–298, 2020, [Online]. Available: https://sid.ir/paper/269887/en

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