CURCUMIN AND ITS DERIVATIVES: MODERATE INHIBITORS OF ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE AND TRYPSIN

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ABBASI M.A.; ILYAS M.; AZIZ UR REHMAN -; SONIA A.; SHAHWAR D.; RAZA M.A.; KHAN K.M.; ASHRAF M.; AFZAL I.; AMBREEN N.

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Paper Information

Journal: Scientia Iranica Year:2012 | Volume:19 | Issue:6 (TRANSACTIONS C: CHEMISTRY AND CHEMICAL ENGINEERING) Page(s): 1580-1583

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Title

CURCUMIN AND ITS DERIVATIVES: MODERATE INHIBITORS OF ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE AND TRYPSIN

Author(s)

Keywords

CURCUMIN

SYNTHETIC DERIVATIVES

ACETYLCHOLINESTERASE

BUTYRYLCHOLINESTERASE

LIPOXYGENASE

TRYPSIN

Abstract

CURCUMIN, a polyphenol yellow orange pigment present in Indian spice “turmeric”, is a member of the ginger family (Zingiberaceae). The extract of turmeric was obtained by using soxhlet apparatus at 45-55 oC, using methanol as solvent and then CURCUMIN was isolated from methanolic extract by column chromatography. In the present study, a series of four new derivatives of CURCUMIN (3a-d) were synthesized by reacting CURCUMIN (1) with different alkyl halides (2a-d) using DMF and lithium hydride. The structures of natural CURCUMIN and its SYNTHETIC DERIVATIVES were confirmed with the help of their 1H-NMR spectra and all these were screened against ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, LIPOXYGENASE and TRYPSIN enzymes. CURCUMIN and its derivatives exhibited moderate inhibitory potential against all aforesaid enzymes.

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APA: Copy

ABBASI, M.A., ILYAS, M., AZIZ UR REHMAN, -, SONIA, A., SHAHWAR, D., RAZA, M.A., KHAN, K.M., ASHRAF, M., AFZAL, I., & AMBREEN, N.. (2012). CURCUMIN AND ITS DERIVATIVES: MODERATE INHIBITORS OF ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE AND TRYPSIN. SCIENTIA IRANICA, 19(6 (TRANSACTIONS C: CHEMISTRY AND CHEMICAL ENGINEERING)), 1580-1583. SID. https://sid.ir/paper/290222/en

Vancouver: Copy

ABBASI M.A., ILYAS M., AZIZ UR REHMAN -, SONIA A., SHAHWAR D., RAZA M.A., KHAN K.M., ASHRAF M., AFZAL I., AMBREEN N.. CURCUMIN AND ITS DERIVATIVES: MODERATE INHIBITORS OF ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE AND TRYPSIN. SCIENTIA IRANICA[Internet]. 2012;19(6 (TRANSACTIONS C: CHEMISTRY AND CHEMICAL ENGINEERING)):1580-1583. Available from: https://sid.ir/paper/290222/en

IEEE: Copy

M.A. ABBASI, M. ILYAS, - AZIZ UR REHMAN, A. SONIA, D. SHAHWAR, M.A. RAZA, K.M. KHAN, M. ASHRAF, I. AFZAL, and N. AMBREEN, “CURCUMIN AND ITS DERIVATIVES: MODERATE INHIBITORS OF ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE AND TRYPSIN,” SCIENTIA IRANICA, vol. 19, no. 6 (TRANSACTIONS C: CHEMISTRY AND CHEMICAL ENGINEERING), pp. 1580–1583, 2012, [Online]. Available: https://sid.ir/paper/290222/en

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