IN VITRO ANTICANCER EVALUATION OF 5-FLUOROURACIL LIPID NANOPARTICLES USING B16F10 MELANOMA CELL LINES

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SHENOY VIKRAM S; GUDE RAJIV P.; RAMACHANDRA MURTHY RAYASA S.

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Journal: INTERNATIONAL NANO LETTERS (INL) Year:2013 | Volume:3 | Issue:3 Page(s): 1-9

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Title

IN VITRO ANTICANCER EVALUATION OF 5-FLUOROURACIL LIPID NANOPARTICLES USING B16F10 MELANOMA CELL LINES

Author(s)

SHENOY VIKRAM S | GUDE RAJIV P. | RAMACHANDRA MURTHY RAYASA S. | Issue Writer Certificate

Keywords

CELL MORPHOLOGY

CETYL PALMITATE

CHEMOSENSITIVITY ASSAY

COLONY FORMATION

GLYCERYL MONOSTEARATE

HOT HOMOGENIZATION

Abstract

The present study is aimed to investigate the formulation andin vitro anticancer activities of solid lipid nanoparticles (SLNs) of 5-fluorouracil (5-FU) prepared using GLYCERYL MONOSTEARATE (GMS) and CETYL PALMITATE (CP) by HOT HOMOGENIZATION method. The lipids were selected based on the partition coefficient of 5-FU in lipids. The lipid nanoparticles were optimized for process and formulation parameters. The optimized nanoparticles were characterized for their zeta potential, morphology, release kinetics, and anticancer activity. Higher entrapments were achieved using a combination of emulsifiers. The zeta potential of the optimized CP and GMS SLN formulation were -8.26 and -9.35 mV, respectively. Both the optimized formulations were spherical. The in vitro release studies of SLNs of both the lipid carriers followed Peppas-Korsenmeyer equation when carried out at pH 3.5 and 7.4. The CHEMOSENSITIVITY ASSAY carried out in B16F10 cell lines revealed that CP SLNs had better cytotoxicity than 5-FU solution and GMS SLNs at 48 h of incubation. Subtoxic concentration of 5-FU-loaded CP SLNs (0.12 mg/mL) possessed comparable antimigrational activity, colony inhibition activity, and cytopathic as that of 5-FU solution effects. The results indicated that encapsulating 5-FU in CP would be a promising delivery system for delivering 5-FU.

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APA: Copy

SHENOY, VIKRAM S, GUDE, RAJIV P., & RAMACHANDRA MURTHY, RAYASA S.. (2013). IN VITRO ANTICANCER EVALUATION OF 5-FLUOROURACIL LIPID NANOPARTICLES USING B16F10 MELANOMA CELL LINES. INTERNATIONAL NANO LETTERS (INL), 3(3), 1-9. SID. https://sid.ir/paper/321419/en

Vancouver: Copy

SHENOY VIKRAM S, GUDE RAJIV P., RAMACHANDRA MURTHY RAYASA S.. IN VITRO ANTICANCER EVALUATION OF 5-FLUOROURACIL LIPID NANOPARTICLES USING B16F10 MELANOMA CELL LINES. INTERNATIONAL NANO LETTERS (INL)[Internet]. 2013;3(3):1-9. Available from: https://sid.ir/paper/321419/en

IEEE: Copy

VIKRAM S SHENOY, RAJIV P. GUDE, and RAYASA S. RAMACHANDRA MURTHY, “IN VITRO ANTICANCER EVALUATION OF 5-FLUOROURACIL LIPID NANOPARTICLES USING B16F10 MELANOMA CELL LINES,” INTERNATIONAL NANO LETTERS (INL), vol. 3, no. 3, pp. 1–9, 2013, [Online]. Available: https://sid.ir/paper/321419/en

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