ATP-SENSITIVE POTASSIUM CHANNELS AND L-TYPE CALCIUM CHANNELS ARE INVOLVED IN MORPHINE-INDUCED HYPERALGESIA AFTER NOCICEPTIVE SENSITIZATION IN MICE

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AHMADI SHAMSEDDIN; AZARIAN SHAHO; EBRAHIMI SAYEDE SHOHRE; REZAYOF AMENEH

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Journal Paper

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Journal: AMIRKABIR Year:2014 | Volume:5 | Issue:3 Page(s): 191-198

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Title

ATP-SENSITIVE POTASSIUM CHANNELS AND L-TYPE CALCIUM CHANNELS ARE INVOLVED IN MORPHINE-INDUCED HYPERALGESIA AFTER NOCICEPTIVE SENSITIZATION IN MICE

Author(s)

AHMADI SHAMSEDDIN | AZARIAN SHAHO | EBRAHIMI SAYEDE SHOHRE | REZAYOF AMENEH | Issue Writer Certificate

Keywords

PAIN BEHAVIOR

SENSITIZATION

MORPHINE

DIAZOXIDE

NIMODIPINE.

Abstract

Introduction: We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in MORPHINE-induced hyperalgesia after nociceptive SENSITIZATION.Methods: We used a hotplate apparatus to assess PAIN BEHAVIOR in male NMRI mice.Nociceptive SENSITIZATION was induced by three days injection of MORPHINE and five days of drug free. On day 9 of the schedule, PAIN BEHAVIOR test was performed for evaluating the effects of MORPHINE by itself and along with NIMODIPINE. a blocker of L-type calcium channels and DIAZOXIDE, an opener of ATP-sensitive potassium channels. All drugs were injected through an intraperitoneal route.Results: The results showed that MORPHINE (7.5, 10 and 15 mg/kg) induced analgesia in normal mice, which was prevented by naloxone (1 mg/kg). After nociceptive SENSITIZATION, analgesic effect of MORPHINE (10 and 15 mg/kg) was significantly decreased in sensitized mice. The results showed that NIMODIPINE.(2.5, 5, 10 and 20 mg/kg) had no significant effect on PAIN BEHAVIOR test in either normal or sensitized mice. However, NIMODIPINE.(20 mg/ kg) along with MORPHINE (10 and 15 mg/kg) caused more decrease in MORPHINE analgesia in sensitized mice. Furthermore, DIAZOXIDE by itself (0.25, 1, 5 and 20 mg/kg) had also no significant effect on PAIN BEHAVIOR in both normal and sensitized mice, but at dose of 20 mg/kg along with MORPHINE (10 and 15 mg/kg) decreased analgesic effect of MORPHINE in sensitized mice.Discussion: It can be concluded that potassium and calcium channels have some roles in decrease of analgesic effect of MORPHINE after nociceptive SENSITIZATION induced by pretreatment of MORPHINE.

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APA: Copy

AHMADI, SHAMSEDDIN, AZARIAN, SHAHO, EBRAHIMI, SAYEDE SHOHRE, & REZAYOF, AMENEH. (2014). ATP-SENSITIVE POTASSIUM CHANNELS AND L-TYPE CALCIUM CHANNELS ARE INVOLVED IN MORPHINE-INDUCED HYPERALGESIA AFTER NOCICEPTIVE SENSITIZATION IN MICE. AMIRKABIR, 5(3), 191-198. SID. https://sid.ir/paper/327734/en

Vancouver: Copy

AHMADI SHAMSEDDIN, AZARIAN SHAHO, EBRAHIMI SAYEDE SHOHRE, REZAYOF AMENEH. ATP-SENSITIVE POTASSIUM CHANNELS AND L-TYPE CALCIUM CHANNELS ARE INVOLVED IN MORPHINE-INDUCED HYPERALGESIA AFTER NOCICEPTIVE SENSITIZATION IN MICE. AMIRKABIR[Internet]. 2014;5(3):191-198. Available from: https://sid.ir/paper/327734/en

IEEE: Copy

SHAMSEDDIN AHMADI, SHAHO AZARIAN, SAYEDE SHOHRE EBRAHIMI, and AMENEH REZAYOF, “ATP-SENSITIVE POTASSIUM CHANNELS AND L-TYPE CALCIUM CHANNELS ARE INVOLVED IN MORPHINE-INDUCED HYPERALGESIA AFTER NOCICEPTIVE SENSITIZATION IN MICE,” AMIRKABIR, vol. 5, no. 3, pp. 191–198, 2014, [Online]. Available: https://sid.ir/paper/327734/en

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