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Information Journal Paper

Title

IMMUNOISOLATION OF STEM CELLS BY SIMULTANEOUS ENCAPSULATION AND PEGYLATION

Pages

  55-60

Keywords

EMBRYONIC STEM CELLS (ESCS) 
TRIMETHYL CHITOSAN (TMC) 

Abstract

 Today, cell therapy is known as an important tool in the treatment of chronic diseases where cells lose their normal function. Immunoisolation systems using MICROENCAPSULATION or PEGYLATION have been developed to evade the problem of rejection by the immune system. The aim of the present study was to investigate a combination of MICROENCAPSULATION and PEGYLATION methods in coating mouse embryonic stem cells (mESCs) to determine its effect in reducing the host’s immune response. Therefore, methoxy polyethylene glycol (mPEG) binding on ALGINATE–trimethyl chitosan (TMC) microcapsules was investigated using FTIR. Furthermore, survival of the microencapsulated mESCs was confirmed using AO/PI staining and MTT assays. In addition, the effect of mESCs co-cultured with foreign lymphocytes was evaluated. Overall, interleukin-2 (IL-2) secretions as a response of the immune system revealed that mESCs MICROENCAPSULATION in ALGINATE–TMC–PEG, reduced the immune system response. The results suggested that IL-2 secretion was reduced to 62% at seventh day.

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    APA: Copy

    RAMEZANZADEH ANDEVARI, ROYA, HASHEMI NAJAFABADI, SAMEEREH, & BAGHERI, FATEMEH. (2018). IMMUNOISOLATION OF STEM CELLS BY SIMULTANEOUS ENCAPSULATION AND PEGYLATION. PROGRESS IN BIOMATERIALS, 7(1), 55-60. SID. https://sid.ir/paper/336521/en

    Vancouver: Copy

    RAMEZANZADEH ANDEVARI ROYA, HASHEMI NAJAFABADI SAMEEREH, BAGHERI FATEMEH. IMMUNOISOLATION OF STEM CELLS BY SIMULTANEOUS ENCAPSULATION AND PEGYLATION. PROGRESS IN BIOMATERIALS[Internet]. 2018;7(1):55-60. Available from: https://sid.ir/paper/336521/en

    IEEE: Copy

    ROYA RAMEZANZADEH ANDEVARI, SAMEEREH HASHEMI NAJAFABADI, and FATEMEH BAGHERI, “IMMUNOISOLATION OF STEM CELLS BY SIMULTANEOUS ENCAPSULATION AND PEGYLATION,” PROGRESS IN BIOMATERIALS, vol. 7, no. 1, pp. 55–60, 2018, [Online]. Available: https://sid.ir/paper/336521/en

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