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Information Journal Paper

Title

CHITOSAN/POLYETHYLENE GLYCOL FUMARATE BLEND FILMS FOR WOUND DRESSINGAPPLICATION: IN VITRO BIOCOMPATIBILITY AND BIODEGRADABILITY ASSAYS

Pages

  143-150

Abstract

 Blending is one of the effective approaches in preparing tailored materials with a wide range of properties. Thus, chitosanbasedpolymers have been fabricated and used as WOUND DRESSINGs since they possess better properties than those of theconstituent materials. The objective of this work was to evaluate the biocompatibility and biodegradability of biodegradableblend films based on polyethylene glycol-co-fumarate (PEGF) and chitosan (Ch). The blend films of Ch/PEGF were preparedby solution casting/solvent evaporation method. Degradation behavior of these blend films was evaluated in a simulatedfluid at physiological pH supplemented with lysozyme at a concentration similar to that in human serum by weight lossof the films and changes in the pH of media. When the pH of incubation media was analyzed, with an increase of PEGFcontent in the blend films, the degradation rate increased accordingly. The pH of the media of samples was not significantlychanged at any measured time point and all films kept their integrities during 28 days. The biocompatibility of the films andcell behavior on the surface of these films were investigated by in vitro tests. Biological assessment using mouse fibroblastcell line L929 on the blend films of Ch/PEGF indicated that films supported the attachment, spreading and proliferation ofcells. Since the Ch/PEGF films are biocompatible with the tailored biodegradation rate, they might have a great prospectiveposition in the application of WOUND DRESSINGs.

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    Cite

    APA: Copy

    HASHEMI DOULABI, AZADEHSADAT, MIRZADEH, HAMID, IMANI, MOHAMMAD, & BAGHERI KHOULENJANI, SHADAB. (2018). CHITOSAN/POLYETHYLENE GLYCOL FUMARATE BLEND FILMS FOR WOUND DRESSINGAPPLICATION: IN VITRO BIOCOMPATIBILITY AND BIODEGRADABILITY ASSAYS. PROGRESS IN BIOMATERIALS, 7(2), 143-150. SID. https://sid.ir/paper/336527/en

    Vancouver: Copy

    HASHEMI DOULABI AZADEHSADAT, MIRZADEH HAMID, IMANI MOHAMMAD, BAGHERI KHOULENJANI SHADAB. CHITOSAN/POLYETHYLENE GLYCOL FUMARATE BLEND FILMS FOR WOUND DRESSINGAPPLICATION: IN VITRO BIOCOMPATIBILITY AND BIODEGRADABILITY ASSAYS. PROGRESS IN BIOMATERIALS[Internet]. 2018;7(2):143-150. Available from: https://sid.ir/paper/336527/en

    IEEE: Copy

    AZADEHSADAT HASHEMI DOULABI, HAMID MIRZADEH, MOHAMMAD IMANI, and SHADAB BAGHERI KHOULENJANI, “CHITOSAN/POLYETHYLENE GLYCOL FUMARATE BLEND FILMS FOR WOUND DRESSINGAPPLICATION: IN VITRO BIOCOMPATIBILITY AND BIODEGRADABILITY ASSAYS,” PROGRESS IN BIOMATERIALS, vol. 7, no. 2, pp. 143–150, 2018, [Online]. Available: https://sid.ir/paper/336527/en

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