مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

229
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

100
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

A new formulation of graphene oxide/fluconazole compound as a promising agent against Candida albicans

Pages

  43-50

Abstract

 Candida albicans (C. albicans) belongs to the opportunistic fungal pathogens, which cause a wide spectrum of infections in immune-compromised patients. Graphene oxide (GO), a biocompatibility agent, has been reported to exhibit effective antimicrobial activity. In the present study, a graphene oxide/Fluconazole (GO/Flu) compound was synthesized and characterized using Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. The antifungal activity of GO/Flu was examined against Fluconazole-resistant C. albicans (ATCC 10231) compared to GO and Flu using the broth microdilution method, according to CLSI protocol. DNA fragmentation was assessed through the antifungal mechanism of GO/Flu. The release of Fluin PBS medium was measured. Moreover, the cytotoxicity effect of GO/Flu on SW480 cell line was evaluated. Indeed, adhesion ability of C. albicans-treated GO/Flu against SW480 cell line was assessed. The minimum inhibitory concentration (MIC) of GO, Flu, and GO/Flu was determined at 800 μ g/mL, 16 μ g/mL, and 400– 9 μ g/mL, respectively. Notably, GO/Flu exhibited an intense antifungal activity compared to GO and Flu. In addition, GO/Flu showed much less cell toxicity against SW480 cell line than GO and Flu (P < 0. 05). The release determination of Flu in PBS (pH 7. 4) medium was 72. 42%. GO/Flu reduced the adhesion ability of C. albicans to SW480 cell line significantly. DNA fragmentation assay indicated that GO/Flu potentially degraded the DNA of C. albicans and caused a fungicidal influence. According to the findings, GO/Flu could enhance the antifungal activity against C. albicans through DNA fragmentation with low cytotoxicity effect.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Asadi Shahi, Sabrieh, ROUDBAR MOHAMMADI, SHAHLA, ROUDBARY, MARYAM, & Delavari, Hamid. (2019). A new formulation of graphene oxide/fluconazole compound as a promising agent against Candida albicans. PROGRESS IN BIOMATERIALS, 8(1), 43-50. SID. https://sid.ir/paper/336545/en

    Vancouver: Copy

    Asadi Shahi Sabrieh, ROUDBAR MOHAMMADI SHAHLA, ROUDBARY MARYAM, Delavari Hamid. A new formulation of graphene oxide/fluconazole compound as a promising agent against Candida albicans. PROGRESS IN BIOMATERIALS[Internet]. 2019;8(1):43-50. Available from: https://sid.ir/paper/336545/en

    IEEE: Copy

    Sabrieh Asadi Shahi, SHAHLA ROUDBAR MOHAMMADI, MARYAM ROUDBARY, and Hamid Delavari, “A new formulation of graphene oxide/fluconazole compound as a promising agent against Candida albicans,” PROGRESS IN BIOMATERIALS, vol. 8, no. 1, pp. 43–50, 2019, [Online]. Available: https://sid.ir/paper/336545/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button