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Information Journal Paper

Title

Co‑ delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic‑ coated iron oxide nanoparticles

Author(s)

 Hiremath Chinmay G. | Heggnnavar Geetha B. | Kariduraganavar Mahadevappa Y. | HIREMATH MURIGENDRA B. | Issue Writer Certificate 

Pages

  155-168

Abstract

 Active targeting of folic acid and passive targeting of magnetic nanoparticles to bring about co-delivery of hydrophobic chemotherapeutic agents were the focus of this work. Co-precipitation in alkaline environment was employed for synthesizing Fe3O4 nanoparticles and stabilized by oleic acid. Aqueous dispersibility of oleic acid coated nanoparticles was brought about by folic acid modified Pluronic F127 and Pluronic F127 mixture. Folic acid is used as a targeting agent which was joined to Pluronic F127 via diethylene glycol bis(3-aminopropyl) ether spacer. The nanocomposite was used to delivery hydrophobic anticancer drugs, Paclitaxel, and curcumin. Successful modification at each step was confirmed by FTIR and NMR. Quantitative analysis of attached folic acid indicated a total of 84. 34% amount of conjugation. Nanoparticles characterization revealed the hydrodynamic size of and nanocomposite to be 94. 2 nm nanometres. Furthermore, transmission electron micrograph reveals the size of the nanoparticle to be 12. 5 nm hence also shows the superparamagnetic activity. Drug encapsulation efficiency of 34. 7% and 59. 5% was noted for Paclitaxel and curcumin, respectively. Cytotoxic property of drug-loaded nanocomposites was increased in case of folic acid functionalized nanoparticles and further increased in the presence of an external magnetic field. Cellular uptake increased in the folic acid conjugated sample. Further many folds in the presence of an external magnetic field.

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    Cite

    APA: Copy

    Hiremath, Chinmay G., Heggnnavar, Geetha B., Kariduraganavar, Mahadevappa Y., & HIREMATH, MURIGENDRA B.. (2019). Co‑ delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic‑ coated iron oxide nanoparticles. PROGRESS IN BIOMATERIALS, 8(3), 155-168. SID. https://sid.ir/paper/336556/en

    Vancouver: Copy

    Hiremath Chinmay G., Heggnnavar Geetha B., Kariduraganavar Mahadevappa Y., HIREMATH MURIGENDRA B.. Co‑ delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic‑ coated iron oxide nanoparticles. PROGRESS IN BIOMATERIALS[Internet]. 2019;8(3):155-168. Available from: https://sid.ir/paper/336556/en

    IEEE: Copy

    Chinmay G. Hiremath, Geetha B. Heggnnavar, Mahadevappa Y. Kariduraganavar, and MURIGENDRA B. HIREMATH, “Co‑ delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic‑ coated iron oxide nanoparticles,” PROGRESS IN BIOMATERIALS, vol. 8, no. 3, pp. 155–168, 2019, [Online]. Available: https://sid.ir/paper/336556/en

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