Study of Selenium Nanoparticles and Sodium Selenite Supplementation Effects on Expression of Leptin Gene in Pregnant Ewes Placenta

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Moayeri Pedram; Kojouri Gholamali; JAFARI AFSHIN; AHADI ALI MOHAMMAD

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Journal: Journal of Veterinary Research Year:2018 | Volume:73 | Issue:4 Page(s): 475-482

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Title

Study of Selenium Nanoparticles and Sodium Selenite Supplementation Effects on Expression of Leptin Gene in Pregnant Ewes Placenta

Author(s)

Moayeri Pedram | Kojouri Gholamali | JAFARI AFSHIN | AHADI ALI MOHAMMAD | Issue Writer Certificate

Keywords

LeptinQ1

Oral administrationQ2

Pregnant ewesQ3

Selenium nanoparticlesQ1

Abstract

BACKGROUND: Leptin as a cytokine-like hormone is derived from ob gene (one of the major effect genes on birth weight and growth traits) and is secreted by adipose tissue. This hormone with binding to its receptors in the hypothalamus, inhibits food intake and increases energy consumption. OBJECTIVES: There is not any report about expression of Leptin gene in response to Oral administration of selenium in livestock. In the present study, the effects of selenium nanoparticle and sodium selenite on the transcription of Leptin gene in placenta were studied. METHODS: Twenty, four-month Pregnant ewes within the same age were selected randomly. During the 21 days leading up to birth, Oral administration of Selenium nanoparticles (Se NPs) with dosages of 0. 05 and 0. 10 mg/kg B. W. and sodium selenite with dosage of 0. 1 mg/ kg B. W. was carried out. At the same time the control group was fed distilled water in equal volume. With sampling of the placenta during childbirth, transcription amount of Leptin gene was determined by RT PCR Real Time based on a comparison assay of 2-Δ Δ Ct. RESULTS: The results of this study showed that Leptin gene is expressed in placental tissue. The Oral administration of selenium nanoparticle and sodium selenite caused a significant increment in terms of expression of mentioned gene in comparison to the control treatment. Also, there was a significant difference between the supplements, so that the highest Leptin gene expression in placenta was observed in selenium nanoparticle treatment with dose of 0. 1 mg and then supplement with Selenium nanoparticles with dose of 0. 05 mg. CONCLUSIONS: Selenium causes an increment of Leptin gene expression in placental tissue.

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APA: Copy

Moayeri, Pedram, Kojouri, Gholamali, JAFARI, AFSHIN, & AHADI, ALI MOHAMMAD. (2018). Study of Selenium Nanoparticles and Sodium Selenite Supplementation Effects on Expression of Leptin Gene in Pregnant Ewes Placenta. JOURNAL OF VETERINARY RESEARCH, 73(4 ), 475-482. SID. https://sid.ir/paper/34803/en

Vancouver: Copy

Moayeri Pedram, Kojouri Gholamali, JAFARI AFSHIN, AHADI ALI MOHAMMAD. Study of Selenium Nanoparticles and Sodium Selenite Supplementation Effects on Expression of Leptin Gene in Pregnant Ewes Placenta. JOURNAL OF VETERINARY RESEARCH[Internet]. 2018;73(4 ):475-482. Available from: https://sid.ir/paper/34803/en

IEEE: Copy

Pedram Moayeri, Gholamali Kojouri, AFSHIN JAFARI, and ALI MOHAMMAD AHADI, “Study of Selenium Nanoparticles and Sodium Selenite Supplementation Effects on Expression of Leptin Gene in Pregnant Ewes Placenta,” JOURNAL OF VETERINARY RESEARCH, vol. 73, no. 4 , pp. 475–482, 2018, [Online]. Available: https://sid.ir/paper/34803/en

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