Immuno-Bioinformatics Study of Autotransporter Protein, Antigen 43, in Enterotoxigenic Escherichia coli Isolated From Calves

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Ghorbanpour Reyhaneh; Nikbakht Gholamreza; JALALI AMIR HOSSEIN

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Journal: Journal of Veterinary Research Year:2019 | Volume:74 | Issue:1 Page(s): 127-141

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Title

Immuno-Bioinformatics Study of Autotransporter Protein, Antigen 43, in Enterotoxigenic Escherichia coli Isolated From Calves

Author(s)

Ghorbanpour Reyhaneh | Nikbakht Gholamreza | JALALI AMIR HOSSEIN | Issue Writer Certificate

Keywords

Immuno-BioinformaticsQ1

Enterotoxigenic Escherichia coli (ETEC)Q1

AutotransporterQ1

Antigen 43Q1

ColibacillosisQ2

Abstract

BACKGROUND: Extensive effort is focused on identifying genomic conserved antigens in development of effective vaccine against Enterotoxigenic Escherichia coli. Antigen 43 is one of the members of a large secreted protein family named Autotransporters in the E. coli and other gram negative bacteria. Autotransporter proteins have a similar conserved structure. Some of them are recognized during both experimental and naturally occurring ETEC infections. Antigen 43 is represented as a potential target in vaccine development because of its virulence functions such as cell aggregation, bioﬁ lm formation and its presence in convalescent sera from human patients with ETEC diarrhea. OBJECTIVES: In this study, we carefully investigate antigenic structure and immunogenicity of the Antigen 43 protein of strain 510 E. coli isolated from calves by experimental methods and immunoinformatics tools. METHODS: Amino acid sequence, physico-chemical parameters, stability, secondary and tertiary protein structure, the ability of induction the B and T cell immune responses by having the effective epitopes and also the allergenicity assessment were analyzed. RESULTS: In this study, we identified 15 peptide sequences that can potentially induce B and T cell immune responses and finally, 9 of them were introduced as antigens. CONCLUSIONS: The results of in-silico analysis on this protein suggested that it can be used in bovine Colibacillosis vaccine development.

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APA: Copy

Ghorbanpour, Reyhaneh, Nikbakht, Gholamreza, & JALALI, AMIR HOSSEIN. (2019). Immuno-Bioinformatics Study of Autotransporter Protein, Antigen 43, in Enterotoxigenic Escherichia coli Isolated From Calves. JOURNAL OF VETERINARY RESEARCH, 74(1 ), 127-141. SID. https://sid.ir/paper/34926/en

Vancouver: Copy

Ghorbanpour Reyhaneh, Nikbakht Gholamreza, JALALI AMIR HOSSEIN. Immuno-Bioinformatics Study of Autotransporter Protein, Antigen 43, in Enterotoxigenic Escherichia coli Isolated From Calves. JOURNAL OF VETERINARY RESEARCH[Internet]. 2019;74(1 ):127-141. Available from: https://sid.ir/paper/34926/en

IEEE: Copy

Reyhaneh Ghorbanpour, Gholamreza Nikbakht, and AMIR HOSSEIN JALALI, “Immuno-Bioinformatics Study of Autotransporter Protein, Antigen 43, in Enterotoxigenic Escherichia coli Isolated From Calves,” JOURNAL OF VETERINARY RESEARCH, vol. 74, no. 1 , pp. 127–141, 2019, [Online]. Available: https://sid.ir/paper/34926/en

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