EVALUATION OF THE EFFECT OF CLOMIPHEN CITRATE ON OSTEOPOROSIS IN THE DOG MODEL: BIOMECHANICAL AND HIDSTOPATHOLOGICAL STUDIES

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SEYFZADEH S.; SHOKOUHI SABET JALALI F.; DERAKHSHANFAR A.

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Journal: Journal of Veterinary Research Year:2006 | Volume:61 | Issue:3 Page(s): 261-264

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Title

EVALUATION OF THE EFFECT OF CLOMIPHEN CITRATE ON OSTEOPOROSIS IN THE DOG MODEL: BIOMECHANICAL AND HIDSTOPATHOLOGICAL STUDIES

Author(s)

SEYFZADEH S. | SHOKOUHI SABET JALALI F. | DERAKHSHANFAR A. | Issue Writer Certificate

Keywords

CLOMIPHEN CITRATEQ3

OSTEOPOROSISQ2

IMMOBILIZATIONQ3

BIOMECHANICSQ3

DOGQ2

Abstract

Objective: To evaluate the short term effect of CLOMIPHEN CITRATE on OSTEOPOROSIS in DOG.Design: Experimental study.Animals: Ten DOGs of both sexes with average weight of 23±5.6 Kg, were randomly assigned to either control (n=5) or experimental groups (n=5).Procedure: OSTEOPOROSIS was induced by immobilizing the right hindlimb by means of fiberglass cast. Five DOGs received CLOMIPHEN CITRATE (5 mg/kg per os) once a day for 42 days. All DOGs were euthanized on day 42 and tibias were harvested. Bone biomechanical properties and microscopic structure of casted and uncasted tibias were studied.Statistical analysis: Independent t-test was done for biomechemical values.Results: Significant differences in the values of examined mechanical properties were found between controt and clomiphen-treated DOGs.(p<0.05) No remarkable histopathological changes were detected in the tibias of casted limb in Clomiphen-treated DOGs.Clinical implications: These findings indicate that short term clomiphen therapy may have promising effects on prevention of OSTEOPOROSIS in DOG.

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APA: Copy

SEYFZADEH, S., SHOKOUHI SABET JALALI, F., & DERAKHSHANFAR, A.. (2006). EVALUATION OF THE EFFECT OF CLOMIPHEN CITRATE ON OSTEOPOROSIS IN THE DOG MODEL: BIOMECHANICAL AND HIDSTOPATHOLOGICAL STUDIES. JOURNAL OF VETERINARY RESEARCH, 61(3), 261-264. SID. https://sid.ir/paper/35268/en

Vancouver: Copy

SEYFZADEH S., SHOKOUHI SABET JALALI F., DERAKHSHANFAR A.. EVALUATION OF THE EFFECT OF CLOMIPHEN CITRATE ON OSTEOPOROSIS IN THE DOG MODEL: BIOMECHANICAL AND HIDSTOPATHOLOGICAL STUDIES. JOURNAL OF VETERINARY RESEARCH[Internet]. 2006;61(3):261-264. Available from: https://sid.ir/paper/35268/en

IEEE: Copy

S. SEYFZADEH, F. SHOKOUHI SABET JALALI, and A. DERAKHSHANFAR, “EVALUATION OF THE EFFECT OF CLOMIPHEN CITRATE ON OSTEOPOROSIS IN THE DOG MODEL: BIOMECHANICAL AND HIDSTOPATHOLOGICAL STUDIES,” JOURNAL OF VETERINARY RESEARCH, vol. 61, no. 3, pp. 261–264, 2006, [Online]. Available: https://sid.ir/paper/35268/en

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