EVALUATION OF ANTI-CANDIDA PROPERTIES OF CATIONIC PEPTIDES DERIVED FROM RANA RIDIBUNDA SKIN

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ERFANMANESH A.; SHOKRI H.A.; HASSAN J.; NIKAEIN D.; GHARIBI S.; BAHONAR A.R.; KHOSRAVI A.R.

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Journal: Journal of Veterinary Research Year:2015 | Volume:70 | Issue:2 Page(s): 119-124

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Title

EVALUATION OF ANTI-CANDIDA PROPERTIES OF CATIONIC PEPTIDES DERIVED FROM RANA RIDIBUNDA SKIN

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Keywords

CATIONIC PEPTIDESQ2

RANA RIDIBUNDAQ2

CANDIDA ALBICANSQ2

CANDIDA GLABRATAQ2

FLUCONAZOLEQ1

Abstract

BACKGROUND: Antimicrobial peptides with relative length (2-100 amino acids) and positive charge (pure charge (+9)-(+2)) are amphiphilic that isolated from a wide range of animals. Recently, these peptides have been known as a part of innate immune response. Nowadays, more than 500 antimicrobial peptides from animals have been reported.OBJECTIVES: The aim of this study was to evaluate the anti-Candida effects of CATIONIC PEPTIDES derived from RANA RIDIBUNDA skin.METHODS: In this study, using alcohol-acid technique, peptides of frog’s skin were isolated and purified by Sep-Pack and Sephadex column. Then the anti-Candida activity (Fluconazole Resistance C. albicans, FLUCONAZOLE Sensitive C. albicans, and C. glabrata) of the peptides in different concentrations were evaluated.RESULTS: Regarding to statistical analysis, peptides in concentration ranging from 25 to 100 mg/ml had the most anti-Candida activities. In respect to different understudy Candida species, these agents had the less effect on the FLUCONAZOLE Resistance C. albicans (p<0.05).CONCLUSIONS: The anti-Candida effects of cationic peptide obtained from frog skin are approved in this study.

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APA: Copy

ERFANMANESH, A., SHOKRI, H.A., HASSAN, J., NIKAEIN, D., GHARIBI, S., BAHONAR, A.R., & KHOSRAVI, A.R.. (2015). EVALUATION OF ANTI-CANDIDA PROPERTIES OF CATIONIC PEPTIDES DERIVED FROM RANA RIDIBUNDA SKIN. JOURNAL OF VETERINARY RESEARCH, 70(2), 119-124. SID. https://sid.ir/paper/35486/en

Vancouver: Copy

ERFANMANESH A., SHOKRI H.A., HASSAN J., NIKAEIN D., GHARIBI S., BAHONAR A.R., KHOSRAVI A.R.. EVALUATION OF ANTI-CANDIDA PROPERTIES OF CATIONIC PEPTIDES DERIVED FROM RANA RIDIBUNDA SKIN. JOURNAL OF VETERINARY RESEARCH[Internet]. 2015;70(2):119-124. Available from: https://sid.ir/paper/35486/en

IEEE: Copy

A. ERFANMANESH, H.A. SHOKRI, J. HASSAN, D. NIKAEIN, S. GHARIBI, A.R. BAHONAR, and A.R. KHOSRAVI, “EVALUATION OF ANTI-CANDIDA PROPERTIES OF CATIONIC PEPTIDES DERIVED FROM RANA RIDIBUNDA SKIN,” JOURNAL OF VETERINARY RESEARCH, vol. 70, no. 2, pp. 119–124, 2015, [Online]. Available: https://sid.ir/paper/35486/en

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