EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF HISTAMINE HI AND H2 ANTAGONISTS ON FOOD INTAKE IN FREELY FEEDING AND FOOD-DEPRIVED RABBITS

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VAFAEI SAYAH GH.R.; TAMADONFARD E.; SHAHROUZ R.

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Journal: Journal of Veterinary Research Year:2005 | Volume:60 | Issue:3 Page(s): 277-282

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Information Journal Paper

Title

EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF HISTAMINE HI AND H2 ANTAGONISTS ON FOOD INTAKE IN FREELY FEEDING AND FOOD-DEPRIVED RABBITS

Author(s)

VAFAEI SAYAH GH.R. | TAMADONFARD E. | SHAHROUZ R. | Issue Writer Certificate

Keywords

BRAINQ2

HISTAMINEQ3

FOOD INTAKEQ3

FREELY FEEDINGQ4

FOOD DEPRIVATIONQ4

RABBITSQ2

Abstract

Objective: To investigate the role of central HISTAMINE H1 and H2 receptors on FOOD INTAKE in FREELY FEEDING and food - deprived RABBITS.Design: Experimental study.Animals: Forty - two male New Zealand white RABBITS weighing between 2.5 - 3 Kg.Procedure: A 23- gauge, 18mm long stainless steel guide cannula was surgically implanted into the lateral ventricle of BRAIN. Intracerebroventricular injections of normal saline (control), promethazine and ranitidine at the same doses of 50, 100 and 200 µg/rabbit in a volume of 5 III were performed using a 25 III Hamilton's syringe.Cumulative FOOD INTAKE was measured in FREELY FEEDING and food - deprived RABBITS at the 0.5, 1,2,3,6 and 24h after injections.Statistical analysis: Paired t-test, Factorial ANOVA and Duncan's test.Results: FOOD DEPRIVATION for I6h increased 0.5, 1,2,3 and 16h cumulative FOOD INTAKE. In FREELY FEEDING RABBITS, promethazine (50 µg) had no effect on FOOD INTAKE, and at the dose of 100 µg increased 1 and 2h feeding after injection, but at the dose of 200 µg increased 2 and 3h postinjection FOOD INTAKE. In the I6h food- deprived RABBITS promethazine (50,100 and 200 µg) had no effect.Ranitidine at the doses of 50,100 and 200 µg produced no significant changes on FOOD INTAKE in both FREELY FEEDING and food- deprived RABBITS. Promethazine did not exert any significant effects on the 6 and 24h post- injection FOOD INTAKE.Conclusion: Based on the results of the present study it is concluded that the blockade of central H1 but not H2 receptors induce a short-lasting excitatory effect on FOOD INTAKE. Thus, central HI receptor may have an important role in the central control of feeding behavior.

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APA: Copy

VAFAEI SAYAH, GH.R., TAMADONFARD, E., & SHAHROUZ, R.. (2005). EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF HISTAMINE HI AND H2 ANTAGONISTS ON FOOD INTAKE IN FREELY FEEDING AND FOOD-DEPRIVED RABBITS. JOURNAL OF VETERINARY RESEARCH, 60(3), 277-282. SID. https://sid.ir/paper/35584/en

Vancouver: Copy

VAFAEI SAYAH GH.R., TAMADONFARD E., SHAHROUZ R.. EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF HISTAMINE HI AND H2 ANTAGONISTS ON FOOD INTAKE IN FREELY FEEDING AND FOOD-DEPRIVED RABBITS. JOURNAL OF VETERINARY RESEARCH[Internet]. 2005;60(3):277-282. Available from: https://sid.ir/paper/35584/en

IEEE: Copy

GH.R. VAFAEI SAYAH, E. TAMADONFARD, and R. SHAHROUZ, “EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF HISTAMINE HI AND H2 ANTAGONISTS ON FOOD INTAKE IN FREELY FEEDING AND FOOD-DEPRIVED RABBITS,” JOURNAL OF VETERINARY RESEARCH, vol. 60, no. 3, pp. 277–282, 2005, [Online]. Available: https://sid.ir/paper/35584/en

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