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Information Journal Paper

Title

THE CENTRAL EFFECTS OF HISTAMINE AND IT'S H1 AND H2 ANTAGONISTS ON BEHAVIOR IN THE RABBIT

Pages

  49-54

Abstract

 Objective: To examine the central role of HISTAMINE and its H1 and H2 receptors on BEHAVIOR in the rabbit.Design: Experimental study Animals: Thirty-five male New Zealand White RABBITS weighing 2 - 2.5 kg. Procedure: Implantation of a 23 - gauge, 15 mm long stainless steel guide cannula into the lateral ventricle of BRAIN, intracerebroventricular injection of normal saline (control), HISTAMINE (50g), promethazine (H1 antagonist, 100 g) and ranitidine (H2 antagonist, 100 g) through the guide cannula with a 25 - 1 hamilton syringe, recording of animal BEHAVIOR including feeding, grooming and locomotion for 1h post - injection.Statistical analysis: One - way ANOVA, Duncans, Multiple Range test and paired t - test. Results: HISTAMINE decreased feeding, grooming and increased locomotion. Promethazine alone, with no effect on grooming, increased feeding and decreased locomotion and pretreatment by it will prevent the HISTAMINE effects on feeding and locomotion, but it will not inhibit the suppressive effect of HISTAMINE on grooming. Ranitidine alone, without any effects on grooming and locomotion, increase feeding and pretreatment by inhabitation the effects of HISTAMINE on feeding. No significant changes observed among control groups. Clinical implication: From the results of this study it is concluded that in the rabbit the BRAIN HISTAMINErgic system via its central H1 receptor produces inhibitory and excitatory effects on feeding and locomotion, respectively. The central H2 receptor may involve in HISTAMINE - induced anorexia too. It also induces a suppressive effect on grooming which is not mediated through it’s central H1 and H2 receptors. In treatment of some BEHAVIORal disorders, the use of blood - BRAIN barrier penetrating H1 and H2 antiHISTAMINEs could be recommended.

Cites

References

Cite

APA: Copy

TAMADONFARD, E., HAJIEGHRARY, N., & MORADY, B.. (2002). THE CENTRAL EFFECTS OF HISTAMINE AND IT'S H1 AND H2 ANTAGONISTS ON BEHAVIOR IN THE RABBIT. JOURNAL OF VETERINARY RESEARCH, 57(3), 49-54. SID. https://sid.ir/paper/34951/en

Vancouver: Copy

TAMADONFARD E., HAJIEGHRARY N., MORADY B.. THE CENTRAL EFFECTS OF HISTAMINE AND IT'S H1 AND H2 ANTAGONISTS ON BEHAVIOR IN THE RABBIT. JOURNAL OF VETERINARY RESEARCH[Internet]. 2002;57(3):49-54. Available from: https://sid.ir/paper/34951/en

IEEE: Copy

E. TAMADONFARD, N. HAJIEGHRARY, and B. MORADY, “THE CENTRAL EFFECTS OF HISTAMINE AND IT'S H1 AND H2 ANTAGONISTS ON BEHAVIOR IN THE RABBIT,” JOURNAL OF VETERINARY RESEARCH, vol. 57, no. 3, pp. 49–54, 2002, [Online]. Available: https://sid.ir/paper/34951/en

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