On the use of Response Surface Methodology for Optimization of Scaffold Composite of the Hydroxyapatite and Diopside

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Rafiee Nasrin; KARBASI SAEID; NOURBAKHSH AMIR ABBAS; AMINI KAMRAN

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Journal Paper

Paper Information

Journal: Journal of Advanced Processes in Materials Engineering Year:2021 | Volume:15 | Issue:2 (57) Page(s): 39-48

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Title

On the use of Response Surface Methodology for Optimization of Scaffold Composite of the Hydroxyapatite and Diopside

Author(s)

Rafiee Nasrin | KARBASI SAEID | NOURBAKHSH AMIR ABBAS | AMINI KAMRAN | Issue Writer Certificate

Keywords

Central Composite DesignQ1

Tissue EngineeringQ2

DiopsideQ2

HydroxyapatiteQ1

ScaffoldQ2

Response Surface MethodologyQ1

Abstract

The Response Surface Methodology is a statistical approach to design the experiments, modeling and analysis of the effective factors as well as to help optimizing the process. In this study, we use the Central Composite Design technique to select the optimum Scaffold composite of the Hydroxyapatite and Diopside. This method suggested twenty different Scaffold specimens by optimizing the suitable percentage of porosity via determining the percentage weight concentrations of the three effective parameters. After making the Scaffold and determining their porosity, the optimum case for composite Scaffolds was 77. 57 wt% nHA (22. 43wt% Di), 0. 64wt% lubricant (STPP) and heat treatment temperature 1200. Also, the results of SEM, FTIR, and XRD confirm that the Scaffold specimen made with the response method is an ideal specimen for use in bone Tissue Engineering. In general, according to the results of this research, the Response Surface Methodology can be a useful tool for optimizing composite Scaffolds in Tissue Engineering.

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APA: Copy

Rafiee, Nasrin, KARBASI, SAEID, NOURBAKHSH, AMIR ABBAS, & AMINI, KAMRAN. (2021). On the use of Response Surface Methodology for Optimization of Scaffold Composite of the Hydroxyapatite and Diopside. ADVANCED PROCESSES IN MATERIALS, 15(2 (57) ), 39-48. SID. https://sid.ir/paper/376342/en

Vancouver: Copy

Rafiee Nasrin, KARBASI SAEID, NOURBAKHSH AMIR ABBAS, AMINI KAMRAN. On the use of Response Surface Methodology for Optimization of Scaffold Composite of the Hydroxyapatite and Diopside. ADVANCED PROCESSES IN MATERIALS[Internet]. 2021;15(2 (57) ):39-48. Available from: https://sid.ir/paper/376342/en

IEEE: Copy

Nasrin Rafiee, SAEID KARBASI, AMIR ABBAS NOURBAKHSH, and KAMRAN AMINI, “On the use of Response Surface Methodology for Optimization of Scaffold Composite of the Hydroxyapatite and Diopside,” ADVANCED PROCESSES IN MATERIALS, vol. 15, no. 2 (57) , pp. 39–48, 2021, [Online]. Available: https://sid.ir/paper/376342/en

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