Comparison of Cytokines Levels Released from Th17 and Regulatory T Cells in Patients with Recurrent Spontaneous Abortions and Healthy Women

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Roumandeh N.; SAREMI A.; Sanaye Naderi M.; YOUNESI B.; ARASTEH J.; ZARE A.

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Journal: SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE) Year:2018 | Volume:3 | Issue:2 Page(s): 93-97

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Title

Comparison of Cytokines Levels Released from Th17 and Regulatory T Cells in Patients with Recurrent Spontaneous Abortions and Healthy Women

Author(s)

Keywords

Abortion

Habitual

Unexplained Recurrent Spontaneous Abortion

Regulatory T Cell

Th17 Cells

Abstract

Aims Unexplained recurrent spontaneous Abortion (URSA) might be caused by an immunological rejection of fetus due to the immune dysregulation during pregnancy. It is supposed that the balance between Th17 and Regulatory T Cells (Treg) is one of the immune system regulatory mechanisms for pregnancy. The objective of the present study was to evaluate the Treg and Th17 cytokines in the women with URSA compared to healthy women. Materials & Methods This case-control study was carried out on 30 women with a history of three or more URSA (case group) and 28 normal healthy women with at least one successful delivery (control group) in Sarem women hospital (Tehran, Iran). The levels of IL-17, IL-21, IL-10 and TGF-β were measured in the serum samples by ELISA method and compared between two groups. The data were analyzed by Mann-Whitney U test and Spearman’ s rank correlation coefficient using SPSS 22 software. Findings The level of IL-17 in the case group was significantly higher than the control group (p<0. 001). Also, the level of TGF-β in the control group was significantly higher than URSA patients (p=0. 001). The serum level of IL-17 showed a positive correlation with TGF-β in URSA group (r=0. 554; p=0. 002). There were no significant differences in IL-21 and IL-10 levels between two groups (p>0. 05). Conclusion The level of IL-17 in patients with URSA is higher than normal healthy women, however, the concentration of TGF-β in women with URSA is lower than healthy women; these findings show that Th17 immunity and Regulatory T Cell-mediated immune regulation are involved in the pathogenesis of URSA.

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APA: Copy

Roumandeh, N., SAREMI, A., Sanaye Naderi, M., YOUNESI, B., & ARASTEH, J.. (2018). Comparison of Cytokines Levels Released from Th17 and Regulatory T Cells in Patients with Recurrent Spontaneous Abortions and Healthy Women. SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE), 3(2 ), 93-97. SID. https://sid.ir/paper/383542/en

Vancouver: Copy

Roumandeh N., SAREMI A., Sanaye Naderi M., YOUNESI B., ARASTEH J.. Comparison of Cytokines Levels Released from Th17 and Regulatory T Cells in Patients with Recurrent Spontaneous Abortions and Healthy Women. SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;3(2 ):93-97. Available from: https://sid.ir/paper/383542/en

IEEE: Copy

N. Roumandeh, A. SAREMI, M. Sanaye Naderi, B. YOUNESI, and J. ARASTEH, “Comparison of Cytokines Levels Released from Th17 and Regulatory T Cells in Patients with Recurrent Spontaneous Abortions and Healthy Women,” SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE), vol. 3, no. 2 , pp. 93–97, 2018, [Online]. Available: https://sid.ir/paper/383542/en

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