Effect of hydroxyapatite nanoparticles on differentiotion of mesenchymal stem cells into bone cells in polycaprolacton/keratin/hydroxyapatite scaffolds

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Kalantari Mina; MAHMOODI MAHBOOBEH; mirhaj marjan

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Journal: Journal of Advanced Processes in Materials Engineering Year:2020 | Volume:14 | Issue:1 Page(s): 55-71

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Information Journal Paper

Title

Effect of hydroxyapatite nanoparticles on differentiotion of mesenchymal stem cells into bone cells in polycaprolacton/keratin/hydroxyapatite scaffolds

Author(s)

Kalantari Mina | MAHMOODI MAHBOOBEH | mirhaj marjan | Issue Writer Certificate

Keywords

ElectrospiningQ2

Mesenchymal Stem CellsQ1

keratinQ2

HydroxyapatiteQ2

Cellular DifferentiationQ2

Nano fibersQ2

PolycaprolactoneQ2

Abstract

The human body process can spontaneously repair small bone defects, while large bone defects cannot be repaired without medical interventions. Efforts to eliminate these shortcomings have led to the foundation of bone tissue engineering. In this research, Polycaprolactone/keratin scaffold and Polycaprolactone/keratin/Hydroxyapatite scaffold were fabricated using electrospinning method and were evaluated. Then, in order to evaluate the Cellular Differentiation, adipose tissue-derived Mesenchymal Stem Cells were cultured on scaffolds and the process of differentiation of Mesenchymal Stem Cells into bone cells for 7 and 14 days was investigated by alkaline phosphatase and alizarin red test. Increase of the activity of the enzyme alkaline phosphatase, the presence of the minerals and the red-orange-color extended on the scaffolds containing Hydroxyapatite nanoparticles that confirmed the presence of Ca + 2, demonstrated the differentiation of mesenchymal cells into bone cells. Therefore, the results of this study suggest that the Polycaprolactone/keratin/Hydroxyapatite scaffold is a suitable substrate for proliferation and differentiation of stem cells for bone tissue engineering.

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APA: Copy

Kalantari, Mina, MAHMOODI, MAHBOOBEH, & mirhaj, marjan. (2020). Effect of hydroxyapatite nanoparticles on differentiotion of mesenchymal stem cells into bone cells in polycaprolacton/keratin/hydroxyapatite scaffolds. ADVANCED PROCESSES IN MATERIALS, 14(1 ), 55-71. SID. https://sid.ir/paper/390419/en

Vancouver: Copy

Kalantari Mina, MAHMOODI MAHBOOBEH, mirhaj marjan. Effect of hydroxyapatite nanoparticles on differentiotion of mesenchymal stem cells into bone cells in polycaprolacton/keratin/hydroxyapatite scaffolds. ADVANCED PROCESSES IN MATERIALS[Internet]. 2020;14(1 ):55-71. Available from: https://sid.ir/paper/390419/en

IEEE: Copy

Mina Kalantari, MAHBOOBEH MAHMOODI, and marjan mirhaj, “Effect of hydroxyapatite nanoparticles on differentiotion of mesenchymal stem cells into bone cells in polycaprolacton/keratin/hydroxyapatite scaffolds,” ADVANCED PROCESSES IN MATERIALS, vol. 14, no. 1 , pp. 55–71, 2020, [Online]. Available: https://sid.ir/paper/390419/en

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