The association between single nucleotide polymorphisms of BRCA1 gene with mastitis in Holstein cattle

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KARAMI MARYAM; Rafat Seyedabbas; MOGHADDAM GHOLAMALI; Shodja Ghiass Jalil; Javanmard Arash

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Journal: Animal Science Journal Year:2018 | Volume:31 | Issue:119 Page(s): 191-208

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Title

The association between single nucleotide polymorphisms of BRCA1 gene with mastitis in Holstein cattle

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Keywords

AlleleQ1

BRCA1 geneQ2

Holstein cattleQ2

mastitisQ1

SNPQ1

Abstract

Enhancing disease resistance in animal production can be achieved by genetic improvement programs. Candidate gene polymorphism is one of the potential approaches for search of association between SNP within this gene phenotype of animals, particularly in MAS for mastitis of large dairy cattle populations. Polymorphism of exon 9 of the BRCA1 gene was investigated by the PCR-RFLP method in 60 Iranian Holstein cattle. In this study, 3 different Alleles were recognized. Polymerase chain reaction-restricted fragment length polymorphism method was used to amplify, digestion and electrophoresis for a 219 base pair of bovine BRCA1 gene. A polymorphism was revealed by G-A single nucleotide polymorphism in +46126 position of BRCA1 gene. Observe genotype frequencies for KK, KL, LL were 0. 27, 0. 43 and 0. 30 respectively, and Allele frequencies for observed K and L Allele were 0. 48 and 0. 52 accordingly. For analysis of variance, normality test and transformation of raw data for SSC records was performed based on previous main reports and literature reviews. GLM and logistic regression methods was used for association study between genotype and collected phenotype. As a final message of the present report, KK genotype was showed significantly affect SCC data and has tendency for low SCC score than other two genotypes. The results of present study indicated BRCA1 gene as an effective candidate gene could be benefit for mastitis resistant in Marker Assisted Selection strategies in dairy cattle.

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APA: Copy

KARAMI, MARYAM, Rafat, Seyedabbas, MOGHADDAM, GHOLAMALI, Shodja Ghiass, Jalil, & Javanmard, Arash. (2018). The association between single nucleotide polymorphisms of BRCA1 gene with mastitis in Holstein cattle. ANIMAL SCIENCES JOURNAL (PAJOUHESH & SAZANDEGI), 31(119 ), 191-208. SID. https://sid.ir/paper/399908/en

Vancouver: Copy

KARAMI MARYAM, Rafat Seyedabbas, MOGHADDAM GHOLAMALI, Shodja Ghiass Jalil, Javanmard Arash. The association between single nucleotide polymorphisms of BRCA1 gene with mastitis in Holstein cattle. ANIMAL SCIENCES JOURNAL (PAJOUHESH & SAZANDEGI)[Internet]. 2018;31(119 ):191-208. Available from: https://sid.ir/paper/399908/en

IEEE: Copy

MARYAM KARAMI, Seyedabbas Rafat, GHOLAMALI MOGHADDAM, Jalil Shodja Ghiass, and Arash Javanmard, “The association between single nucleotide polymorphisms of BRCA1 gene with mastitis in Holstein cattle,” ANIMAL SCIENCES JOURNAL (PAJOUHESH & SAZANDEGI), vol. 31, no. 119 , pp. 191–208, 2018, [Online]. Available: https://sid.ir/paper/399908/en

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