GAMMA ORYZANOL BEARING NANOLIPOSOME PRODUCED BY MODIFIED THERMAL METHOD: THERMAL PROPERTY, ENCAPSULATION EFFICIENCY, OSCILLATORY RHEOMETRY

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MOHAMMAD HASSANI ZAHRA; GHANBARZADEH BABAK; HAMISHEHKAR HAMED; REZAYI MOKARRAM REZA; HOSEINI MOHAMMADYAR

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Journal: Iranian Journal of Polymer Science and Technology Year:2014 | Volume:26 | Issue:5 (ISSUE NO. 127) Page(s): 413-425

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Title

GAMMA ORYZANOL BEARING NANOLIPOSOME PRODUCED BY MODIFIED THERMAL METHOD: THERMAL PROPERTY, ENCAPSULATION EFFICIENCY, OSCILLATORY RHEOMETRY

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Keywords

NANOLIPOSOMEQ2

GAMMA-ORYZANOLQ2

DSCQ2

STABILITYQ3

OSCILLATORY RHEOLOGYQ2

Abstract

NANOLIPOSOMEs are one of the most important polar lipid-based nanocarriers which can be used for encapsulation of both hydrophilic and hydrophobic active compounds. In this research, NANOLIPOSOMEs based on lecithin- polyethylene glycol-gamma oryzanol were prepared by using a modified thermal method. Only one melting peak in DSC curve of gamma oryzanol bearing liposomes was observed which could be attributed to co-crystallization of both compounds. The addition of gamma oryzanol, caused to reduce the melting point of 5% (w/v) lecithin-based liposome from 207°C to 163.2°C. At high level of lecithin, increasing of liposome particle size (storage at 4°C for two months) was more obvious and particle size increased from 61 and 113 to 283 and 384 nanometers, respectively. The encapsulation efficiency of gamma oryzanol increased from 60% to 84.3% with increasing lecithin content. The encapsulation STABILITY of oryzanol in liposome was determined at different concentrations of lecithin 3, 5, 10, 20% (w/v) and different storage times (1, 7, 30 and 60 days). In all concentrations, the encapsulation STABILITY slightly decreased during 30 days storage. The scanning electron microscopy (SEM) images showed relatively spherical to elliptic particles which indicated to low extent of particles coalescence. The oscillatory rheometry showed that the loss modulus of liposomes were higher than storage modulus and more liquid-like behavior than solid- like behavior. The samples storage at 25oC for one month, showed higher viscoelastic parameters than those having been stored at 4oC which were attributed to higher membrane fluidity at 25oC and their final coalescence.

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APA: Copy

MOHAMMAD HASSANI, ZAHRA, GHANBARZADEH, BABAK, HAMISHEHKAR, HAMED, REZAYI MOKARRAM, REZA, & HOSEINI, MOHAMMADYAR. (2014). GAMMA ORYZANOL BEARING NANOLIPOSOME PRODUCED BY MODIFIED THERMAL METHOD: THERMAL PROPERTY, ENCAPSULATION EFFICIENCY, OSCILLATORY RHEOMETRY. IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN), 26(5 (ISSUE NO. 127)), 413-425. SID. https://sid.ir/paper/401337/en

Vancouver: Copy

MOHAMMAD HASSANI ZAHRA, GHANBARZADEH BABAK, HAMISHEHKAR HAMED, REZAYI MOKARRAM REZA, HOSEINI MOHAMMADYAR. GAMMA ORYZANOL BEARING NANOLIPOSOME PRODUCED BY MODIFIED THERMAL METHOD: THERMAL PROPERTY, ENCAPSULATION EFFICIENCY, OSCILLATORY RHEOMETRY. IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN)[Internet]. 2014;26(5 (ISSUE NO. 127)):413-425. Available from: https://sid.ir/paper/401337/en

IEEE: Copy

ZAHRA MOHAMMAD HASSANI, BABAK GHANBARZADEH, HAMED HAMISHEHKAR, REZA REZAYI MOKARRAM, and MOHAMMADYAR HOSEINI, “GAMMA ORYZANOL BEARING NANOLIPOSOME PRODUCED BY MODIFIED THERMAL METHOD: THERMAL PROPERTY, ENCAPSULATION EFFICIENCY, OSCILLATORY RHEOMETRY,” IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN), vol. 26, no. 5 (ISSUE NO. 127), pp. 413–425, 2014, [Online]. Available: https://sid.ir/paper/401337/en

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