+14bp/-14bp Polymorphism of HLA-G Gene in Iranian Women with Recurrent Spontaneous Abortions

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Paknahad B.; SAADATNIA G.; MIRZA AHMADI S.; SALEHIAN P.

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Paper Information

Journal: SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE) Year:2018 | Volume:3 | Issue:2 Page(s): 99-103

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Information Journal Paper

Title

+14bp/-14bp Polymorphism of HLA-G Gene in Iranian Women with Recurrent Spontaneous Abortions

Author(s)

Paknahad B. | SAADATNIA G. | MIRZA AHMADI S. | SALEHIAN P. | Issue Writer Certificate

Keywords

14+bp/14

bp Polymorphism;HLA

G Gene;Abortion

Habitual;HLA

G Antigens

Abstract

Aims Spontaneous abortion is one of the most common complications of pregnancy. Human leukocyte antigen G (HLA-G) is thought to have a mediating role in mother and fetus interactions. The aim of this study was to investigate the association of the +14bp/-14bp polymorphism of HLA-G gene with recurrent spontaneous abortion (RSA) among Iranian women. Materials & Methods This case-control study was conducted on 50 patients with RSA and 50 normal women referred to Sarem women hospital (Tehran, Iran) during a six-month period from October 2012 to March 2013. After preparation of the blood samples and extraction of DNA, the exon 8 of HLA-G gene was amplified by polymerase chain reaction (PCR) and observed by polyacrylamide gel electrophoresis. Statistical analysis of data was done by Chi-square test using SPSS software. Findings There was a significant difference in the frequency of homozygous genotypes between patient and control groups (p=0. 034). The homozygous genotypes of +14bp or-14bp were found more frequently in patients with RSA (60%) than the control group (34%). The odds ratio (OR) for homozygous genotypes relative to heterozygote genotype was found as 2. 91. Conclusion The frequencies of heterozygous and homozygous genotypes of the polymorphism, +14bp/-14bp of the HLA-G gene, differ between Iranian women with a history of RSA and healthy women.

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APA: Copy

Paknahad, B., SAADATNIA, G., MIRZA AHMADI, S., & SALEHIAN, P.. (2018). +14bp/-14bp Polymorphism of HLA-G Gene in Iranian Women with Recurrent Spontaneous Abortions. SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE), 3(2 ), 99-103. SID. https://sid.ir/paper/401510/en

Vancouver: Copy

Paknahad B., SAADATNIA G., MIRZA AHMADI S., SALEHIAN P.. +14bp/-14bp Polymorphism of HLA-G Gene in Iranian Women with Recurrent Spontaneous Abortions. SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;3(2 ):99-103. Available from: https://sid.ir/paper/401510/en

IEEE: Copy

B. Paknahad, G. SAADATNIA, S. MIRZA AHMADI, and P. SALEHIAN, “+14bp/-14bp Polymorphism of HLA-G Gene in Iranian Women with Recurrent Spontaneous Abortions,” SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE), vol. 3, no. 2 , pp. 99–103, 2018, [Online]. Available: https://sid.ir/paper/401510/en

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