ASCORBIC ACID DIMINISHES DEVELOPMENTAL DAMAGES INDUCED BY HIGH GLUCOSE IN MOUSE PRE-IMPLANTATION EMBRYOS IN VITRO

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AMIRI I.; BARBARESTANI M.; MARZBAN H.; NEMAT ELAHI N.; NIKNAFS B.

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Journal: ARCHIVES OF RAZI INSTITUTE Year:2001 | Volume:- | Issue:52 Page(s): 75-86

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Title

ASCORBIC ACID DIMINISHES DEVELOPMENTAL DAMAGES INDUCED BY HIGH GLUCOSE IN MOUSE PRE-IMPLANTATION EMBRYOS IN VITRO

Author(s)

Keywords

HIGH GLUCOSE

APOPTOSIS

ASCORBIC ACID

PRE-IMPLANTATION EMBRYO

MOUSE

ANTIOXIDANT

Abstract

Diabetic teratogenicity seems that to be related to embryonic oxidative stress and the extent of the embryonic damage can apparently be reduced by ANTIOXIDANTs. In this study, 2-cell stage embryos of normal mice were cultured for 96 h with a high concentration of glucose (30 mM) in the absence or presence of 1 mM L-ascorbic acid (LAA). In the end of culture, the morphology of embryos was assessed with the aid of inverted phase-contrast microscope, and also cell APOPTOSIS was studies by TUNEL (TdT-mediated conjugated dupt nick end-Labeling) technique. Result: High glucosis alone decreased the blastosyst formation and increased the incidence of embryo fragmentation and cell APOPTOSIS. With LAA, the incidence of high glucosis induced embryo fragmentation and cell APOPTOSIS was decreased, on the contrary the incidence of blastocyst formation was increased.

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APA: Copy

AMIRI, I., BARBARESTANI, M., MARZBAN, H., NEMAT ELAHI, N., & NIKNAFS, B.. (2001). ASCORBIC ACID DIMINISHES DEVELOPMENTAL DAMAGES INDUCED BY HIGH GLUCOSE IN MOUSE PRE-IMPLANTATION EMBRYOS IN VITRO. ARCHIVES OF RAZI INSTITUTE, -(52), 75-86. SID. https://sid.ir/paper/529141/en

Vancouver: Copy

AMIRI I., BARBARESTANI M., MARZBAN H., NEMAT ELAHI N., NIKNAFS B.. ASCORBIC ACID DIMINISHES DEVELOPMENTAL DAMAGES INDUCED BY HIGH GLUCOSE IN MOUSE PRE-IMPLANTATION EMBRYOS IN VITRO. ARCHIVES OF RAZI INSTITUTE[Internet]. 2001;-(52):75-86. Available from: https://sid.ir/paper/529141/en

IEEE: Copy

I. AMIRI, M. BARBARESTANI, H. MARZBAN, N. NEMAT ELAHI, and B. NIKNAFS, “ASCORBIC ACID DIMINISHES DEVELOPMENTAL DAMAGES INDUCED BY HIGH GLUCOSE IN MOUSE PRE-IMPLANTATION EMBRYOS IN VITRO,” ARCHIVES OF RAZI INSTITUTE, vol. -, no. 52, pp. 75–86, 2001, [Online]. Available: https://sid.ir/paper/529141/en

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