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Information Journal Paper

Title

EFFECTS OF AFLATOXIN B1 ON LIVER NUCLEAR DNA BIOSYNTHESIS IN GROWING AND DAY-OLD CHICKENS

Pages

  57-65

Abstract

 The inhibitory effects of AFLATOXIN B1 (AFB1) on hepatic DNA BIOSYNTHESIS was compared in growing and day-old CHICKENs. A single ip dose of AFB1 (0, 25, 50,100 or 200mμg/kg BW) was administered to groups of then and day-old female Hybro-broiler CHICKENs pre-treated with [3H]-thymidine. All the CHICKENs were given labeled thymidine 22h prior to AFB1 administration and sacrificed 2h after AFB1 injection. LIVERs were removed and processed for DNA isolation and estimation of thymidine incorporation into nuclear DNA. A differential inhibitory effect of AFB1 on DNA BIOSYNTHESIS in hen and chicks was noticed. The overall results showed that as compared to growing CHICKENs, youngers are relatively more refractory to AFB1-induced inhibition in DNA BIOSYNTHESIS. A single dose of AFB1 (25.50, 100 or 200 mμg/kg BW) administered to day-old CHICKENs caused on average 22-28% inhibition in DNA BIOSYNTHESIS. Whereas under similar conditions of dose and treatment to the growing group, a greater (36-47%) but dose-dependent inhibition in hens LIVER DNA is recorded.

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    • Cite

    APA: Copy

    PARHIZKAR, A., MIRHADI, S.A., & ALAMEH, A.. (2002). EFFECTS OF AFLATOXIN B1 ON LIVER NUCLEAR DNA BIOSYNTHESIS IN GROWING AND DAY-OLD CHICKENS. ARCHIVES OF RAZI INSTITUTE, -(53), 57-65. SID. https://sid.ir/paper/530131/en

    Vancouver: Copy

    PARHIZKAR A., MIRHADI S.A., ALAMEH A.. EFFECTS OF AFLATOXIN B1 ON LIVER NUCLEAR DNA BIOSYNTHESIS IN GROWING AND DAY-OLD CHICKENS. ARCHIVES OF RAZI INSTITUTE[Internet]. 2002;-(53):57-65. Available from: https://sid.ir/paper/530131/en

    IEEE: Copy

    A. PARHIZKAR, S.A. MIRHADI, and A. ALAMEH, “EFFECTS OF AFLATOXIN B1 ON LIVER NUCLEAR DNA BIOSYNTHESIS IN GROWING AND DAY-OLD CHICKENS,” ARCHIVES OF RAZI INSTITUTE, vol. -, no. 53, pp. 57–65, 2002, [Online]. Available: https://sid.ir/paper/530131/en

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