PATHOGENICITY AND IMMUNOGENICITY OF NATIVE AND MUTANT STRAINS OF PASTEURELLA MULTOCIDA, THE CAUSATIVE AGENTS OF HAEMORRHAGIC SEPTICAEMIA

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TABATABAEI M.; MOAZENI JOULA GH.R.; JABARI A.R.; ESMAEILZADEH M.

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Paper Information

Journal: IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR) Year:2007 | Volume:8 | Issue:1 (18) Page(s): 40-44

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Title

PATHOGENICITY AND IMMUNOGENICITY OF NATIVE AND MUTANT STRAINS OF PASTEURELLA MULTOCIDA, THE CAUSATIVE AGENTS OF HAEMORRHAGIC SEPTICAEMIA

Author(s)

TABATABAEI M. | MOAZENI JOULA GH.R. | JABARI A.R. | ESMAEILZADEH M. | Issue Writer Certificate

Keywords

PASTEURELLA MULTOCIDA

LIVE VACCINE

AROA MUTANT

HAEMORRHAGIC SEPTICAEMIA

Abstract

Haemorrhagic septicaemia (HS) is a fatal systemic disease of cattle and buffaloes. Some control is achieved with administration of alum-precipitated or oil-adjuvanted killed whole-cell vaccines injected subcutaneously. These vaccines, however, provide only short-term immunity and for effective use, they should be administered annually. We constructed an aroA attenuated derivative of a PASTEURELLA MULTOCIDA serotype B:2 strain by allelic exchange of the native aroA sequence with aroA sequences disrupted with a kanamycin resistance cassette. This strain was confirmed to be AROA MUTANT by PCR. The aroA derivative was highly attenuated for virulence in a mouse model of HS and rabbits. Mouse and rabbit challenge experiments showed that i.p. or i.m. vaccination of an aroA strain completely protected mice or rabbits against challenge with a high dose (>1000 LD50) of the parent strain.

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APA: Copy

TABATABAEI, M., MOAZENI JOULA, GH.R., JABARI, A.R., & ESMAEILZADEH, M.. (2007). PATHOGENICITY AND IMMUNOGENICITY OF NATIVE AND MUTANT STRAINS OF PASTEURELLA MULTOCIDA, THE CAUSATIVE AGENTS OF HAEMORRHAGIC SEPTICAEMIA. IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR), 8(1 (18)), 40-44. SID. https://sid.ir/paper/533338/en

Vancouver: Copy

TABATABAEI M., MOAZENI JOULA GH.R., JABARI A.R., ESMAEILZADEH M.. PATHOGENICITY AND IMMUNOGENICITY OF NATIVE AND MUTANT STRAINS OF PASTEURELLA MULTOCIDA, THE CAUSATIVE AGENTS OF HAEMORRHAGIC SEPTICAEMIA. IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR)[Internet]. 2007;8(1 (18)):40-44. Available from: https://sid.ir/paper/533338/en

IEEE: Copy

M. TABATABAEI, GH.R. MOAZENI JOULA, A.R. JABARI, and M. ESMAEILZADEH, “PATHOGENICITY AND IMMUNOGENICITY OF NATIVE AND MUTANT STRAINS OF PASTEURELLA MULTOCIDA, THE CAUSATIVE AGENTS OF HAEMORRHAGIC SEPTICAEMIA,” IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR), vol. 8, no. 1 (18), pp. 40–44, 2007, [Online]. Available: https://sid.ir/paper/533338/en

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