OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS ON NOVEL THREE-DIMENSIONAL POLY(L-LACTIC ACID)/CHITOSAN/GELATIN/B-TRICALCIUM PHOSPHATE HYBRID SCAFFOLDS

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MOHAMMADI YOUSEF; MIRZADEH HAMID; MOZTARZADEH F.; SOLEYMANI MASOUD; JABARI EBRAHIM

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Journal: Iranian Polymer Journal Year:2007 | Volume:16 | Issue:1 (79) Page(s): 57-69

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Title

OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS ON NOVEL THREE-DIMENSIONAL POLY(L-LACTIC ACID)/CHITOSAN/GELATIN/B-TRICALCIUM PHOSPHATE HYBRID SCAFFOLDS

Author(s)

Keywords

BONE

CHITOSAN

HYBRID SCAFFOLD

TISSUE ENGINEERING

STEM CELL

Abstract

The concept of combining synthetic polymers with naturally derived biopolymers and resorbable bioceramics has been recently considered as an effective solution for orthopedic TISSUE ENGINEERING. In the present study, based on a biomimetic approach, a novel 3D biodegradable porous hybrid biomaterial consisting of poly(L-lactic acid) (PLLA), CHITOSAN, gelatin, and b-tricalcium phosphate (b-TCP) was developed. Macroporous LLA/b-TCP scaffolds were prepared by freezeextraction/ particulate leaching method and embedded with porous CHITOSAN/gelatin/b - TCP sponges. The influences of chemical, physical, and structural properties of the scaffolds prepared on the attachment and differentiation of mesenchymal STEM CELLs into osteoblasts and the proliferation of the differentiated cells were investigated. Osteogenically induced cultures revealed that cells were well-attached, penetrated into the scaffold and uniformly distributed. The expression of early and late phenotypic markers of osteoblastic differentiation was upregulated in the scaffolds cultured in osteogenic medium.

Cites

BIOCOMPATIBILITY AND BIODEGRADATION OF POLY (D,L-LACTIC-CO-GLYCOLIC ACID) 90/10: IN VITRO AND IN VIVO ASSAYS

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APA: Copy

MOHAMMADI, YOUSEF, MIRZADEH, HAMID, MOZTARZADEH, F., SOLEYMANI, MASOUD, & JABARI, EBRAHIM. (2007). OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS ON NOVEL THREE-DIMENSIONAL POLY(L-LACTIC ACID)/CHITOSAN/GELATIN/B-TRICALCIUM PHOSPHATE HYBRID SCAFFOLDS . IRANIAN POLYMER JOURNAL (ENGLISH), 16(1 (79)), 57-69. SID. https://sid.ir/paper/550659/en

Vancouver: Copy

MOHAMMADI YOUSEF, MIRZADEH HAMID, MOZTARZADEH F., SOLEYMANI MASOUD, JABARI EBRAHIM. OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS ON NOVEL THREE-DIMENSIONAL POLY(L-LACTIC ACID)/CHITOSAN/GELATIN/B-TRICALCIUM PHOSPHATE HYBRID SCAFFOLDS . IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2007;16(1 (79)):57-69. Available from: https://sid.ir/paper/550659/en

IEEE: Copy

YOUSEF MOHAMMADI, HAMID MIRZADEH, F. MOZTARZADEH, MASOUD SOLEYMANI, and EBRAHIM JABARI, “OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS ON NOVEL THREE-DIMENSIONAL POLY(L-LACTIC ACID)/CHITOSAN/GELATIN/B-TRICALCIUM PHOSPHATE HYBRID SCAFFOLDS ,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 16, no. 1 (79), pp. 57–69, 2007, [Online]. Available: https://sid.ir/paper/550659/en

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