A NANOFIBROUS COMPOSITE SCAFFOLD OF PCL/HYDROXYAPATITE-CHITOSAN/PVA PREPARED BY ELECTROSPINNING

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ZARGARIAN S.S.H.; HADADIASL V.

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Journal: Iranian Polymer Journal Year:2010 | Volume:19 | Issue:6 (120) Page(s): 457-468

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Title

A NANOFIBROUS COMPOSITE SCAFFOLD OF PCL/HYDROXYAPATITE-CHITOSAN/PVA PREPARED BY ELECTROSPINNING

Author(s)

ZARGARIAN S.S.H. | HADADIASL V. | Issue Writer Certificate

Keywords

TISSUE ENGINEERING

NANOFIBRES

ELECTROSPINNING

SCAFFOLD

OSTEOGENIC DIFFERENTIATION

Abstract

TISSUE ENGINEERING SCAFFOLDs produced by ELECTROSPINNING feature a structural similarity with the natural extracellular matrices. In this study, for the first time, poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) and chitosan/poly(vinyl alcohol) (PVA) were simultaneously electrospun from two different syringes and mixed on a rotating drum to prepare homogeneous nanofibrous composite SCAFFOLD. The concentration of the spinning solutions and the ratios of PCL/HA-chitosan/PVA were varied and adjusted to acquire NANOFIBRES with narrow diameter distribution. It was found that the PCL/HA spun fibres became thick and non-uniform in diameter by decreasing the solution concentration and voltage, and yet the effect of flow rate was negligible. Meanwhile, the diameters of chitosan/PVA fibres decreased and became more uniform by decreasing the solution concentration and tip-to-target distance. Furthermore, HA nanocrystals reinforce the SCAFFOLD and increase its mechanical strength, though by changing its mechanical behaviour make it more brittle. SEM morphology of the PCL/HA electrospun nanocomposite revealed that HA nanocrystals were kept suspended in solution during the ELECTROSPINNING process, and laid inside the PCL NANOFIBRES. This feature may provide a mechanism for controlled release of HA nanoparticles in cell culture studies. It was assumed that the nanofibrous composite SCAFFOLD of electrospun PCL/HA-chitosan/PVA can potentially be used for the OSTEOGENIC DIFFERENTIATION of stem cells.

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APA: Copy

ZARGARIAN, S.S.H., & HADADIASL, V.. (2010). A NANOFIBROUS COMPOSITE SCAFFOLD OF PCL/HYDROXYAPATITE-CHITOSAN/PVA PREPARED BY ELECTROSPINNING. IRANIAN POLYMER JOURNAL (ENGLISH), 19(6 (120)), 457-468. SID. https://sid.ir/paper/562340/en

Vancouver: Copy

ZARGARIAN S.S.H., HADADIASL V.. A NANOFIBROUS COMPOSITE SCAFFOLD OF PCL/HYDROXYAPATITE-CHITOSAN/PVA PREPARED BY ELECTROSPINNING. IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2010;19(6 (120)):457-468. Available from: https://sid.ir/paper/562340/en

IEEE: Copy

S.S.H. ZARGARIAN, and V. HADADIASL, “A NANOFIBROUS COMPOSITE SCAFFOLD OF PCL/HYDROXYAPATITE-CHITOSAN/PVA PREPARED BY ELECTROSPINNING,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 19, no. 6 (120), pp. 457–468, 2010, [Online]. Available: https://sid.ir/paper/562340/en

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