مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

The effects of captopril on lipopolysaccharide-induced sickness behaviors in rats

Pages

  199-205

Abstract

 Neuro-immune mediators play an important role in the development of Sickness behaviors. In the present study, the effect of Captopril on Sickness behaviors caused by Lipopolysaccharide (LPS) was studied in the Rats. The animals were randomized into the following groups: control, sham, 10 mg kg-1 Captopril-LPS (Capto 10-LPS), 50 mg kg-1 Captopril-LPS (Capto 50-LPS), and 100 mg kg-1 Captopril-LPS (Capto 100-LPS). Behavioral tests including open-field (OF), elevated plus maze (EPM) and forced swimming (FS) test were performed, and the serum level of Interleukin-6 (IL-6) was assessed. In OF, the number of crossings in the central zone in Capto 10-LPS, Capto 50-LPS, and Capto 100-LPS groups was higher than that of the sham group. In EPM, the open arm entry numbers in the sham group were lower compared to the control group. Furthermore, pretreatment by Captopril increased the entries to the open arms. In FS test, the immobility time of the sham group was longer than that of the control group. In Capto 10-LPS, Capto 50-LPS, and Capto 100-LPS groups, immobility was shorter compared to the sham group. In addition, the IL-6 level was higher in the sham group compared to the control group, and treatment with 50 and 100 mg kg-1 of Captopril restored the IL-6 level in comparison with the sham group. Results confirmed that pretreatment with Captopril amelioRated LPS-caused Sickness behaviors and attenuated IL-6 as an inflammatory marker in the Rats.

Cites

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    • Cite

    APA: Copy

    ABARESHI, AZAM, ANAEIGOUDARI, AKBAR, NOROUZI, FATEMEH, Marefati, Narges, BEHESHTI, FARIMAH, SAEEDJALALI, MOHSEN, & HOSSEINI, MAHMOUD. (2019). The effects of captopril on lipopolysaccharide-induced sickness behaviors in rats. VETERINARY RESEARCH FORUM, 10(3), 199-205. SID. https://sid.ir/paper/724981/en

    Vancouver: Copy

    ABARESHI AZAM, ANAEIGOUDARI AKBAR, NOROUZI FATEMEH, Marefati Narges, BEHESHTI FARIMAH, SAEEDJALALI MOHSEN, HOSSEINI MAHMOUD. The effects of captopril on lipopolysaccharide-induced sickness behaviors in rats. VETERINARY RESEARCH FORUM[Internet]. 2019;10(3):199-205. Available from: https://sid.ir/paper/724981/en

    IEEE: Copy

    AZAM ABARESHI, AKBAR ANAEIGOUDARI, FATEMEH NOROUZI, Narges Marefati, FARIMAH BEHESHTI, MOHSEN SAEEDJALALI, and MAHMOUD HOSSEINI, “The effects of captopril on lipopolysaccharide-induced sickness behaviors in rats,” VETERINARY RESEARCH FORUM, vol. 10, no. 3, pp. 199–205, 2019, [Online]. Available: https://sid.ir/paper/724981/en

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